Results 81 to 90 of about 836,867 (274)

Histone variants: essential actors in male genome programming

, 2017
International audiencePrior to its transmission to the offspring, the male genome has to be tightly compacted. A genome-scale histone eviction and the subsequent repackaging of DNA by protamines (Prms) direct this essential genome condensation step.
Alexandra Vargas, Rousseaux, Sophie, Saadi Khochbin, Barral, Sophie, Vargas, Alexandra, Sophie Rousseaux, Naghmeh Hoghoughi, Sophie Barral, Khochbin, Saadi, Hoghoughi, Naghmeh   +9 more
core   +1 more source

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina, Becker, Peter B., Maier, Verena K.   +2 more
core   +1 more source

Histone variants take center stage in shaping the epigenome

, 2021
The dynamic properties of the nucleosome are central to genomic activity. Variants of the core histones that form the nucleosome play a pivotal role in modulating nucleosome structure and function.
Borg, M. ; https://orcid.org/, Berger, F., Jiang, D.   +2 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Influence of change in the proportion of H1 histone variants on microsporogenesis and development of male gametophyte in transgenic plants of tobacco (Nicotiana tabacum L.)

Acta Societatis Botanicorum Poloniae, 2011
As continuation of investigations in to the mechanism of the role of the H1 histone, which is a crucial protein component chromosomes of all eukaryotes, transgenic tobacco plants with different levels of the H1 histone variants were examined. Tobacco has
Joanna Ślusarczyk, Andrzej Wierzbicki, Marcin Przewłoka, Teresa Tykarska, Andrzej Jerzmanowski, Mieczysław Kuraś   +5 more
doaj   +1 more source

Histone complement of a rapidly evolving chordate Oikopleura dioica: Developmental and sex-specific deployment of novel and universal histone variants and their posttranslational modifications [PDF]

, 2007
The packaging of DNA into nucleosomes is a fundamentally conserved property of the eukaryotic nucleus which is evident in the conservation of histone sequences. Nevertheless, it is now clear that histone sequence variants have diversified in many species
Moosmann, Alexandra, R. Malgara, M. R. Sansò, M.G. Grimoldi, C. Vener, F. Ripamonti, A. Iurlo, F. Radaelli, A. Benevento, S. Buiatiotis, R. Busuito   +10 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A catalog of potential putative functional variants in psoriasis genome-wide association regions. [PDF]

PLoS ONE, 2018
Psoriasis is a common inflammatory skin disease, with considerable genetic contribution. Genome-wide association studies have successfully identified a number of genomic regions for the risk of psoriasis.
Yan Lin, Lu Liu, Yujun Sheng, Changbing Shen, Xiaodong Zheng, Fusheng Zhou, Sen Yang, Xianyong Yin, Xuejun Zhang   +8 more
doaj   +1 more source

Studying the Evolution of Histone Variants Using Phylogeny

, 2018
International audienceHistones wrap DNA to form nucleosomes that package eukaryotic genomes. Histone variants have evolved for diverse functions including gene expression, DNA repair, epigenetic silencing, and chromosome segregation.
Ines A. Drinnenberg, Antoine Molaro, Drinnenberg, Ines, Molaro, Antoine   +3 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source