Results 91 to 100 of about 93,929 (281)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian, Sebastian Pünzeler (381339), Gunnar Schotta (116394), Jack, Antonia P. M., Michael Wells (381341), Bussemer, Silva, Martha Snyder (381340), Hake, Sandra B., Matthias Hahn, Irina Solovei, Solovei, Irina, Hahn, Matthias, Wells, Michael, Gunnar Schotta, Sebastian Pünzeler, Martha Snyder, Sandra B. Hake (165089), Matthias Hahn (209009), Antonia P. M. Jack (381337), Irina Solovei (85), Sandra B Hake, Silva Bussemer, Michael Wells, Antonia P M Jack, Silva Bussemer (381338), Gyorgyi Csankovszki (5654086), Snyder, Martha, Schotta, Gunnar, Csankovszki, Gyorgyi, Gyorgyi Csankovszki   +29 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Histone variants and histone exchange

, 2006
Histories, as basic components of nucleosome. are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants ...
Gui Jian-Fang (jfgui@ihb.ac.cn), Wu Nan (wunan@ihb.ac.cn), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Peoples R China, Wu Nan   +3 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Filter-Aided Sample Preparation Procedure for Mass Spectrometric Analysis of Plant Histones

Frontiers in Plant Science, 2018
Characterization of histone post-translational modifications (PTMs) is still challenging, and robust histone sample preparation is essential for convincing evaluation of PTMs by mass spectrometry.
Dominika Ledvinová, Dominika Ledvinová, Kamil Mikulášek, Kamil Mikulášek, Hana Kuchaříková, Hana Kuchaříková, Sylva Brabencová, Sylva Brabencová, Miloslava Fojtová, Miloslava Fojtová, Zbyněk Zdráhal, Zbyněk Zdráhal, Gabriela Lochmanová   +12 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height. [PDF]

, 2011
The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes.
Cole, Trevor, Tatton-Brown, Katrina, Douglas, Jenny, Sheila Seal, Loveday, C, Patton, Michael, A Splitt, Ruark, E, Patricia Wheeler, Ra Hanks, Michael Patton, Murray, A, Katie Snape, Ramsay, Emma, Seal, Sheila, Clare Taylor, Ramsay, E, Volker Strenger, Taylor, C, Vivienne Mcconnell, Zachariou, A, Temple, KI, Loveday, Chey, Tatton-Brown, K, Patton, M, Temple, IK, Katrina Tatton-brown, Duarte, SDELV, Seal, S, Douglas, J, Jenny Douglas, Raith, W, Clericuzio, Carol, Temple, I. Karen, Magee, A, Anne Murray, Flinter, F, ?, ?, Splitt, Miranda, Banka, S, Rahman, N, Strenger, V, Flinter, Frances, Trevor Cole, Rankin, Julia, Carol Clericuzio, Snape, Katie, Zachariou, Anna, Temple, Karen I, Anna Zachariou, Murray, Anne, Splitt, M, Julia Rankin, Temple, Karen I., Nazneen Rahman, Elise Ruark, Wheeler, P, Magee, Alex, Childhood Overgrowth Collaboration, The Childhood Overgrowth, Strenger, Volker, Duarte, SDV, I Karen Temple, McConnell, Vivienne, Perdeaux, Elizabeth R, Banka, Siddharth, Clericuzio, C, Hanks, Sandra, Siddharth Banka, Del Vecchio Duarte, Frances Flinter, Wheeler, Patricia, Emma Ramsay, Ruark, Elise, Banka, Siddharth; id_orcid, McConnell, V, Elizabeth R, Perdeaux, ER, Cole, T, Taylor, Clare, Snape, K, Raith, Wolfgang, Chey Loveday, Rahman, Nazneen, Duarte, Silvana Del Vecchio, Hanks, S, Perdeaux, Elizabeth R., Alex Magee, Rankin, J   +88 more
core   +1 more source

Distribution of linker histone variants during plant cell differentiation in the developmental zones of the maize root, dedifferentiation in callus culture after auxin treatment

Biological Research, 2008
Although several linker histone variants have been studied in both animal and plant organisms, little is known about their distribution during processes that involve alterations in chromatin function, such as differentiation, dedifferentiation and ...
ANASTASIOS ALATZAS, LJUBA SREBREVA, ATHINA FOUNDOULI   +2 more
doaj