Results 131 to 140 of about 317,398 (334)
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
EVIDENCE For THE CYTOPLASMIC SYNTHESIS OF NUCLEAR HISTONE DURING SPERMIOGENESIS IN THE GRASSHOPPER CHORTOPHAGA VIRIDIFASCIATA (DE GEER) [PDF]
, 1964 David P. Bloch, Sheilah D. Brack
openalex +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
THE SYNTHESES OF DEOXYRIBONUCLEIC ACID AND HISTONE IN THE ONION ROOT MERISTEM [PDF]
, 1967 David P. Bloch +3 more
openalex +1 more source
Advanced Biology, EarlyView.HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang +6 more
wiley +1 more source
Varying Specificity of Systemic Lupus Erythematosus Sera for Histone Fractions and a Periodatesensitive Antigen Associated with Histone [PDF]
, 1969 B. David Stollar
openalex +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
"Open" chromatin : histone acetylation, linker histones & histone variants
, 2013 DNA in the eukaryotic cell is packaged into a structure called chromatin. Chromatin is a dynamic structure that regulates access to DNA in response to environmental stimuli. Two widely conserved mechanisms that influence chromatin structure are the addition of post-translational modifications (PTMs) to histones and other chromatin-associated proteins ...
openaire +2 more sources
Emerging roles of linker histones in regulating chromatin structure and function
Nature reviews. Molecular cell biology, 2017 D. Fyodorov +3 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong +15 more
wiley +1 more source