Results 181 to 190 of about 245,589 (335)

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Uterine Histone Secretion Likely Fosters Early Embryo Development So Efforts to Mitigate Histone Cytotoxicity Should Be Cautious

Frontiers in Cell and Developmental Biology, 2017
Lon J. Van Winkle, Lon J. Van Winkle
doaj   +1 more source

DNA Wrapping by a tetrameric bacterial histone. [PDF]

Nat Commun
Hu Y, Schwab S, Qiu K, Zhang Y, Bär K, Reichle H, Panzera A, Lupas AN, Hartmann MD, Dame RT, Alva V, Hernandez Alvarez B.   +11 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase interacts with novel Drosophila ribosomal proteins, L22 and L23a, with unique histone-like amino-terminal extensions

, 1999
Yumi Koyama, Shoichiro Katagiri, Shuji Hanai, Kazuhiko Uchida, Masanao Miwa   +4 more
openalex   +1 more source

Nucleosome-free Region Dominates Histone Acetylation in Targeting SWR1 to Promoters for H2A.Z Replacement [PDF]

, 2013
Anand Ranjan, Gaku Mizuguchi, Peter Fitzgerald, Debbie Wei, Feng Wang, Yingzi Huang, Ed Luk, Christopher L. Woodcock, Carl Wu   +8 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Damage-associated molecular patterns and coagulation. [PDF]

Br J Haematol
Yong J, Toh CH.
europepmc   +1 more source

Genome-wide identification and analysis of GH1-containing H1 histones among poplar species [PDF]

Ping Li, Jing Wang, Qi-Min Zhang, Aimin Yu, Rui Sun, Aizhong Liu   +5 more
openalex   +1 more source

Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres [PDF]

, 2019
María Isabel Navarro-Mendoza, Carlos Pérez‐Arques, Shweta Panchal, Francisco E. Nicolás, Stephen J. Mondo, Promit Ganguly, Jasmyn Pangilinan, Igor V. Grigoriev, Joseph Heitman, Kaustuv Sanyal, Victoriano Garre   +10 more
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source