Results 201 to 210 of about 111,769 (244)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Chromatin Regulation of HSV Gene Transcription. [PDF]

Viruses
Zheng Y, Zhang J, Pan D.
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Breaking Boundaries in Histone Modification MS-Based Detection: A Tailored Search Strategy for Unrestricted Identification of Novel Epigenetic Marks. [PDF]

Mol Cell Proteomics
Vai A, Noberini R, Graziadei A, Polasky DA, Yu F, Nesvizhskii AI, Bonaldi T.   +6 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD. [PDF]

Sci Adv
Yudin D, Jaskolowski M, Fan Z, Burg N, Chandrasekar S, Lentzsch AM, Scaiola A, Bothe A, Deuerling E, Gamerdinger M, Shan SO, Ban N.   +11 more
europepmc   +1 more source

Reply to Chen: Methodological and analytical considerations in the study of H3-Dendra2 distribution. [PDF]

Proc Natl Acad Sci U S A
Li A, Tong D, Ohlstein B, Guo Z.
europepmc   +1 more source

Pulmonary Arterial Hypertension: Reconfiguring the Vascular Landscape to Reverse Remodeling. [PDF]

Cells
Vassiliou AG, Papavassiliou KA, Lotsios NS, Orfanos SE, Papavassiliou AG.   +4 more
europepmc   +1 more source

Epigenetic Changes in Alzheimer's Disease and Interventions for Therapy. [PDF]

Neuropsychiatr Dis Treat
Xu M, Xiong L, Qin Z, Yu X, Chen T, Zhang X, Jin M, Wang L, Cai L, Wei Y, Liu H, Wang C, Hu H, Zou Z.   +13 more
europepmc   +1 more source

Neutrophil Extracellular Traps in Systemic Lupus Erythematosus: Pathogenic Mechanisms, Crosstalk with Oxidative Stress, and Antioxidant Therapeutic Potential. [PDF]

Antioxidants (Basel)
Chen X, Gao D, Wang M, Wang L, Hu H, Wen C, Tang Y.   +6 more
europepmc   +1 more source