Results 81 to 90 of about 239,429 (335)

Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress

Journal of Extracellular Vesicles
Histones are conserved nuclear proteins that function as part of the nucleosome in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, and when elevated, may ...
Birendra Singh, Marcus Fredriksson Sundbom, Uma Muthukrishnan, Balasubramanian Natarajan, Stephanie Stransky, André Görgens, Joel Z. Nordin, Oscar P. B. Wiklander, Linda Sandblad, Simone Sidoli, Samir El Andaloussi, Michael Haney, Jonathan D. Gilthorpe   +12 more
doaj   +1 more source

Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons

Cells
Neurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic mechanisms are known to play crucial roles in learning and memory, neuron-specific genome-wide ...
Brandon Signal, Andrew J. Phipps, Katherine A. Giles, Shannon N. Huskins, Timothy R. Mercer, Mark D. Robinson, Adele Woodhouse, Phillippa C. Taberlay   +7 more
doaj   +1 more source

Structure and function of archaeal histones. [PDF]

PLoS Genetics, 2018
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman, Clara van Emmerik, Hugo van Ingen, Remus T Dame   +3 more
doaj   +1 more source

Non-mammalian model organisms in epigenetic research : an overview [PDF]

, 2020
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +3 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Hansemann’s anaplastic theory of cancer after 135 years

Frontiers in Epigenetics and Epigenomics
Summary: The term “anaplasia” was coined in 1890 to describe chromosomal changes common to primordial cancer cells, but ever since the mechanisms whereby a cell becomes anaplastic has been the subject of much speculation.
Steven Henikoff, Steven Henikoff, Kami Ahmad   +2 more
doaj   +1 more source

Diversity and Divergence of Dinoflagellate Histone Proteins

G3: Genes, Genomes, Genetics, 2016
Histone proteins and the nucleosomal organization of chromatin are near-universal eukaroytic features, with the exception of dinoflagellates. Previous studies have suggested that histones do not play a major role in the packaging of dinoflagellate ...
Georgi K. Marinov, Michael Lynch
doaj   +1 more source

The Snf2 Homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme [PDF]

, 2010
The Saccharomyces cerevisiae Fun30 (Function unknown now 30) protein shares homology with an extended family of Snf2-related ATPases. Here we report the purification of Fun30 principally as a homodimer with a molecular mass of about 250 kDa.
Adra, Ahmed H. Hassan, Barton, Becker, Bruno, Cairns, Clark, Collins, Daniel Ryan, Dillingham, Ferreira, Ferreira, Flaus, Flaus, Gavin, Hartley, Hassan, Hassan, Kouzarides, Krogan, Lowary, Luger, Mizuguchi, Neves-Costa, Okazaki, Ouspenski, Papamichos-Chronakis, Philippe Prochasson, Puig, Racki, Salma Awad, Schoor, Schoor, Shih, Smith, Soininen, Stockdale, Strohner, Suter, Thåström, Tom Owen-Hughes, Ubersax, Whitehouse, Zofall   +43 more
core   +4 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources