Results 121 to 130 of about 1,389,299 (344)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Generative AI in Heritage Practice: Improving the Accessibility of Heritage Guidance
HeritageThis paper discusses the potential for integrating Generative Artificial Intelligence (GenAI) into professional heritage practice with the aim of enhancing the accessibility of public-facing guidance documents.
Jessica Witte +4 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
The Impact of Age on the Value of historic homes in a Nationally Recognized Historic District [PDF]
This paper uses hedonic modeling to test the effects of age, both actual and effective, on the value of historic properties within a nationally recognized historic district.
Dawn Jourdan +2 more
core
Final proposal to encode the Cuneiform script in the SMP of the UCS [PDF]
, 2004 This is a proposal to encode the Phoenician script in the international character encoding standard Unicode. This script was published in Unicode Standard version 5.0 in July 2006.
Everson, Michael
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Experience + Interaction [PDF]
, 2011 What do our historic sites and museums offer to visitors? More importantly, what should we strive to offer? Right now, I think many of our historic sites offer two different things: a variety of experiences and access to a wealth of information.
Dinkelaker, Jacob
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Stochastic Micro-Modelling of Historic Masonry [PDF]
, 2021 John Adamek, P. Kabele
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source