Results 141 to 150 of about 1,368,556 (344)
Artificial Intelligence for Routine Heritage Monitoring and Sustainable Planning of the Conservation of Historic Districts: A Case Study on Fujian Earthen Houses (Tulou) [PDF]
Jiayue Fan, Yile Chen, Liang Zheng
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Preliminary Cultural Resources Investigations for the Pharr-Reynosa International Bridge, Hidalgo County, Texas [PDF]
, 1993 Archeological, archival, and geomorphologic investigations were conducted for the proposed Pharr-Reynosa International Bridge Project in Hidalgo County, Texas, by Prewitt and Associates, Inc. from October 12-27, 1992. The purposes of these investigations
Earls, Amy C. +2 more
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, 2010 The phenomenon of yawning is just as intriguing and fascinating as sleep, yet understanding of its causes and consequences has defied the human mind for centuries. Hippocrates, Sennert, Boerhaave and de Gorter each advanced a theory in his time. From the release of tainted humor to the awakening of animal spirits and improved brain oxygenation, the ...
openaire +2 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Journal of Computer Applications in ArchaeologyThe Atlas of Hillforts of Britain and Ireland is a large open dataset published online for reuse and reinterpretation. This data is large and complex, making it challenging to manipulate, especially in a discipline where a lack of data literacy skills is
Mike Middleton
doaj +1 more source
The Twenty-Fifth Amendment to the United States Constitution: A Reader\u27s Guide [PDF]
, 2018 Historic overview and analysis of presidential succession coupled with findings of the law ...
Yale Law School Rule of Law Clinic
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