Results 61 to 70 of about 480,938 (253)

Merging Special Collections with GIS Technology to Enhance the User Experience [PDF]

open access: yes, 2016
This analysis evaluates how PhillyHistory.org merged their unique special collection materials with geospatial-based progressive technology to challenge and educate the global community.
Nichols, Gina L
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Teaching and Research Tasks in the Pharmaceutical Services Profile in Cienfuegos in 2010

open access: yesMedisur, 2011
Background: it is of utmost importance to conduct research to theoretically substantiate how to achieve a better academic and intellectual preparation of students.
Loreta Sánchez Ortiz   +5 more
doaj   +2 more sources

Seismic behavior and assessment of masonry heritage structures. Needs in engineering judgement and education

open access: yesRILEM Technical Letters, 2019
Built cultural heritage is at risk due to manmade and natural hazards. The seismic vulnerability of ancient masonry buildings is particularly difficult to assess and requires specialized technical skills.
Paulo Lourenco, Georgios Karanikoloudis
doaj   +1 more source

A sustainable tourism development in Alacati, Turkey : (Re)invention of public space with clean energy [PDF]

open access: yes, 2013
Although there is an increasing recognition of the impacts of climate change on communities, residents often resist changing their lifestyle to reduce the effects of the problem.
Buys, Laurie, Ozgun, Kaan
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A radiocarbon database for Scottish archaeological samples [PDF]

open access: yes, 2000
For the majority of dating laboratories and their respective user communities, the journal Radiocarbon is no longer regarded as the medium for primary publication of radiocarbon measurements.
Ashmore, P.J.   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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