Results 81 to 90 of about 1,526,402 (238)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Energy Performance Certificates and Historic Apartment Buildings: A Method to Encourage User Participation and Sustainability in the Refurbishment Process

The Historic Environment: Policy & Practice, 2019
This article presents and discusses the challenges of refurbishing historic apartment buildings by correlating findings from research projects LEAF and CulClim.
F. Berg, A. Donarelli
semanticscholar   +1 more source

Historic Preservation Program newsletter [PDF]

, 2017
2017. UNIVERSITY OF VERMONT HISTORIC PRESERVATION PROGRAM HISTORY DEPARTMENT - WHEELER HOUSE - BURLINGTON, VERMONThttps://scholarworks.uvm.edu/hpnewsletter/1009/thumbnail ...
Historic Preservation Program newsletter,
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Scottish Archaeological Research Framework: Future Thinking on Carved Stones [PDF]

, 2016
No abstract ...
Buckham, Susan, Forsyth, Katherine, Foster, Sally, Jeffrey, Stuart   +3 more
core  

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

TO THE SOURCES OF DIACHRONIC SOCIOLINGUISTICS: GLOBAL EXPERIENCE AND UKRAINIAN PROBLEMATICS

Записки з українського мовознавства, 2017
The subject of the suggested research is a new sphere of sociolinguistics – diachronic sociolinguistics: its sources, subject of the research and tasks.
І. Д. Фаріон
doaj   +1 more source

Rights, Resources, Rezoning and the Challenges of Governance in South Africa's Oldest Marine Protected Area

Conservation & Society, 2020
This research examines the rezoning of Africa's oldest Marine Protected Area (MPA), the Tsitsikamma National Park (TNP) MPA. In December 2016, the TNP MPA was rezoned from 'no-take' to a partially open MPA to provide access for local fishing communities.
Ella-Kari Muhl, Merle Sowman
doaj   +1 more source

Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study

International Journal of Environmental Research and Public Health, 2016
Background: The relationship between preterm birth (PTB) and endocrine disruptor exposure in drinking-water has only occasionally been studied. The objective of this work was to investigate the relation between exposure to atrazine metabolites, or ...
M. Albouy-Llaty, F. Limousi, C. Carles, A. Dupuis, S. Rabouan, V. Migeot   +5 more
semanticscholar   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source