Results 101 to 110 of about 2,005,241 (310)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
ImagesThe article addresses the problem of narrativizing the past in a digital ego-documentary using the example of the game Cosmic Top Secret (Klassefilm, 2018), directed by Trine Laier.
Marcin Pigulak
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Theorica et Practica: Historical Epistemology and the Re-Visioning of Thirteenth and Fourteenth-Century Medicine [PDF]
, 2011 Positivist medical historians, guided by the savoir of modern western biomedicine, have long depicted medieval medicine as an aberration along the continuum of scientific and medical progress.
Gardenour, Brenda S.
core
Influence of geography on language competition
, 2008 Competition between languages or cultural traits diffusing in the same geographical area is studied combining the language competition model of Abrams and Strogatz and a human dispersal model on an inhomogeneous substrate.
Abrams +31 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
How the Russian Orthodox Church Views the Russian World
, 2015 The cultural concept of a “Russian world” (Russian: “russkiy mir”) plays an increasingly important role today, and is not limited to political discourse.
Bremer, Thomas
core
Human Cattle: Prison Overpopulation and the Political Economy of Mass Incarceration [PDF]
, 2016 This paper examines the costs and impacts of prison overpopulation and mass incarceration on individuals, families, communities, and society as a whole.
Hanna, Peter
core +1 more source