Results 111 to 120 of about 2,002,135 (290)

Influence of geography on language competition

, 2008
Competition between languages or cultural traits diffusing in the same geographical area is studied combining the language competition model of Abrams and Strogatz and a human dispersal model on an inhomogeneous substrate.
Abrams, Ammerman, Baronchelli, Baronchelli, Bouchaud, Castelló, Castelló, Davison, Els Heinsalu, Hadzibeganovic, Ke, Lipowski, Lomolino, Loreto, Marco Patriarca, Martino, Minett, Mira, Murray, Nichols, Nowak, Patriarca, Pinasco, Press, Schulze, Schulze, Schulze, Stauffer, Stauffer, Steels, Wang, Wichmann   +31 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Long-Run Weight of Communism or the Weight of Long-Run History? [PDF]

This study provides evidence that culture understood as values and beliefs moves very slowly. Despite massive institutional change, values and beliefs in transition countries have not changed much over the last 20 years. Evidence suggests that culture is
Roland, Gerald
core  

Inventing the Gothic Subject: Revolution, Secularization, and the Discourse of Suffering [PDF]

, 2002
In 1816, Byron\u27s Childe Harold bemoaned: What deep wounds ever closed without a scar?/The heart\u27s bleed longest, and but heal to wear/That which disfigures it (III, 84), a fitting expression of the culture\u27s fascination with psychic, emotional,
Hoeveler, Diane
core   +1 more source

The Anthropological and Social Consequences of the Triadic Logic: A Proposal for Adapting the Logic Model to Life Thinking

Religions
Modernity is characterised by a specific scientific paradigm based on binary logic. Neither freedom nor creativity have a place in this logical model. On the contrary, triadic logic enables rational consideration of an anthropological and social model ...
Teresa Aizpun
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Historical consciousness and strategies of detraumatization of historical culture in the modern world

Studia Humanitatis, 2019
The article presents the socio-philosophical analysis of detraumatization and its main strategies in modern historical culture. Detraumatization was interpreted as the cultural practice of reformatting the semantic structure of relations between the past
Linchenko Andrei Aleksandrovich
doaj  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source