Results 41 to 50 of about 2,005,241 (310)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Latent and explicit mnemonic communities on social media: studying digital memory formation through hashtag co-occurrence analysis

Memory, Mind & Media
This article explores the nature and dynamics of mnemonic communities within the context of social media platforms and proposes to identify mnemonic communities using hashtag co-occurrence analysis.
Robbert-Jan Adriaansen
doaj   +1 more source

The Air Torpedo of Bäckebo: Local Incident and World History

Current Swedish Archaeology, 2006
In June 1944 a German V2-rocket exploded and crashed in Bäckebo in the province of Småland in southern Sweden. Technically the rocket represented the most modern the world had seen at the time.
Mats Burström, Anders Gustafsson, Håkan Karlsson   +2 more
doaj   +1 more source

Deep semantic segmentation of unmanned aerial vehicle remote sensing images based on fully convolutional neural network

Frontiers in Earth Science, 2023
In the era of artificial intelligence and big data, semantic segmentation of images plays a vital role in various fields, such as people’s livelihoods and the military.
Guoxun Zheng, Guoxun Zheng, Guoxun Zheng, Zhengang Jiang, Hua Zhang, Hua Zhang, Hua Zhang, Xuekun Yao, Xuekun Yao   +8 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Online Surveillance in a Swedish Context: Between acceptance and resistance

Nordicom Review, 2020
Users of digital media leave traces that corporations and authorities can harvest, systematise, and analyse; on the societal level, an overall result is the emergence of a surveillance culture.
Cocq Coppélie, Gelfgren Stefan, Samuelsson Lars, Enbom Jesper   +3 more
doaj   +1 more source

The process of civilization (and its discontents): violence, narrative and history [PDF]

, 2005
Historical violence studies are being increasingly influenced by theoretical approaches which focus on the development of ‘cultures of violence’. However, this growing interest in the interconnections between violence and culture faces a number of ...
Wood, J.Carter
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Sacred Theater in Goguryeo Tomb Murals: Myth, Belief, and the Pictorial Performance of Political Authority

Religions
The 4th and 5th centuries marked a pivotal phase in the development of the Goguryeo regime. Its tomb murals epitomize the visual strategies of state-building, serving to establish a “sacred theater” of power. Taking Tomb No.
Lu Yang
doaj   +1 more source

Local as a tool for teaching history: how do experiential knowledge permeate teaching in the young municipalities of Baixada Fluminense?

Didattica della storia, 2020
The present work aimed to analyze the construction of narratives that can manifest the historical culture of the municipalities of Belford Roxo, Queimados, Japeri and Mesquita, emancipated from Nova Iguaçu at the turn of the 20th century for this century.
Claudia Patrícia de Oliveira Costa
doaj   +1 more source