Results 131 to 140 of about 2,221,083 (311)
Citizenship and the Politics of Civic Driven Change [PDF]
, 2012 Nation states are premised on the legitimizing presence of a polity comprised of citizens. The politics of this relationship is central to discourse on how societies evolve.
Alan Fowler, Kees Biekart
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The Health Status of Southern Children: A Neglected Regional Disparity
, 2005 Purpose: Great variations exist in child health outcomes among states in the United States, with southern states consistently ranked among the lowest in the country.
Bryant, Thomas +7 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Territorial context in the research on the EU cohesion. One-speed or multi-speed Europe? [PDF]
Every European Union enlargement has deepened economical divergence between member states and their regions. However, the economic aspect of this issue is only a part of a broad scope of reasons of its internal diversity, including also social, cultural ...
Mariusz Sokołowicz
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Is Africa Different? Historical Conflict and State Development [PDF]
, 2014 We show that the consequences of historical warfare for state development differ for Sub-Saharan Africa. We identify the locations of more than 1,500 conflicts in Africa, Asia, and Europe from 1400 to 1799.
Dincecco, Mark +2 more
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Masterclass: international law and constitutional development in 19th century Europe (Part II) [PDF]
, 2015 1. Today, Hungary is a small Central-Eastern-European country making headlines with its domestic political and constitutional controversies. Yet, throughout its 1000-year history, this country had many struggles and developments, which, when put into a ...
Beke-Martos, Judit
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source