Results 101 to 110 of about 349,501 (319)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Immersive Reconstruction of the Sriwijaya Kingdom: Developing a Metaverse-Based Learning Environment for Cultural Preservation

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
This research's purpose is to create and subsequently confirm the efficacy of a virtual world-based learning experience representing a bygone civilization, specifically the Srivijaya Empire, as part of a project to digitally preserve and teach about ...
Yudi Pratama, Neni Wahyuningtyas, Bayu Kurniawan   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Russian historical films in the digital educational environment: didactic models and criteria for evaluating the effectiveness of media texts

Russian Journal of Education and Psychology
Background. The digital transformation of Russian schools has brought to the fore the task of methodologically correctly incorporating audiovisual media texts into the digital educational environment.
Dmitry A. Belyaev, Ivan N. Skripkin
doaj   +1 more source

Philosophical and Historical Vision of Educational Researches

Filosofiya osvity. Philosophy of Education, 2019
The article provides an analytical review of the monograph “Education and “Pädagogik”: Philosophical and Historical Reflections (Central, Southern and Southeast Europe)” edited by Slovak professors B. Kudláčová and A. Rajský. This collective monograph is the result of the creative collaboration of 26 scientists from 13 countries on the initiative of ...
openaire   +3 more sources

On the role of openness in education: A historical reconstruction [PDF]

, 2013
In the context of education, “open(ness)” has become the watermark for a fast growing number of learning materials and associated platforms and practices from a variety of institutions and individuals.
Sandra Peter, Peter, Sandra, Markus Deimann, Deimann, Markus   +3 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Advances in ethics education in the history classroom: after intersections of moral and historical consciousness [PDF]

Using the history classroom as a context for ethics and moral education is a long, but also contested, tradition. Recently, more emphasis has been put on how to incorporate ethics education, with this paper exploring the spaces of ethics and moral ...
Sharp Heather, Ammert Niklas, Edling Silvia, Löfström Jan   +3 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

THE FORMATION OF THE NATIONAL IDENTITY OF STUDENTS IN THE STUDY OF THE COURSE "HISTORY"

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015
The article discusses the importance of teaching the course "History" in high school for the formation of national identity of modern Russian society. Historical memory is regarded as the basis of national identity.
Natalia A. Tatarenkova
doaj