Results 81 to 90 of about 11,849,902 (308)
Hodnoty a hodnocení v dějepise // Values and judgements in history teaching [PDF]
Historie - Otázky - Problémy, 2017 The study presents different approaches of foreign largely Anglo-Saxon history teaching methods to moral judgements in history teaching, and using several probes, illustrates the nature of moral judgements in the Czech educational milieu.
Jaroslav Pinkas
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EXPERIENCE IN ORGANIZING PATRIOTIC EDUCATION AT CLASSICAL UNIVERSITY
Высшее образование в России, 2016 The article describes the experience of the educational work of the lecturers of historical-geographical faculty of the CSU of I.N. Ulyanov. A combination of manifold forms and methods in this area of educational activity ensures its efficiency. CSU of I.
Oleg N. Shirokov +4 more
doaj
Научный диалогThis study examines how Turkey’s external and internal political orientations during the Cold War (1945–1991) shaped the perception of Soviet Russia and Russia in general, as well as how this process was reflected in school history textbooks.
A. Çelik, H. Bingöl
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Asian Flu Pandemic in Indonesia, 1957: Government and Public Response
IHiS (Indonesian Historical Studies)This study aims to analyze the 1957 Asian Flu Pandemic in Indonesia, focusing on the government and public response. The 1957 Asian Flu Pandemic was the second pandemic in the world after the 1918 Spanish Flu Pandemic. The pandemic was caused by the H2N2
Muhammad Fakhriansyah +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source