Results 61 to 70 of about 71,035 (266)

Delirium and historical project

open access: yes, 2008
Thesis: wissenschaftliche Zeitschrift der Bauhaus-Universität Weimar, vol. 49, 2003, no.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Narrativas de histórias: um estudo preliminar na gestão de projetos de tecnologia da informação Historical narratives: a preliminary study on management of projects of information technology

open access: yesCiência da Informação, 2008
Narrativas de histórias é uma técnica de gestão do conhecimento para compartilhamento de experiências, pensamentos e valores no ambiente organizacional.
Valério Brusamolin, Eduardo Moresi
doaj   +1 more source

The Historical Workstation Project : Part 1

open access: yes, 1991
Historical Social Research, 16(4), 51 ...
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Enriching Historical Manuscripts: The Bovary Project [PDF]

open access: yes, 2004
In this paper we describe the Bovary Project, a manuscripts digitization project of the famous French writer Gustave FLAUBERT's first great work, which should end in 2006 by providing an online access to an hypertextual edition of "Madame Bovary" drafts set.
Nicolas, Stéphane   +2 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

The Chilean Plebiscite: Projections Without Historic Data

open access: yesJournal of the American Statistical Association, 1992
Abstract On October 5, 1988, Chileans decided by plebiscite to oust General Pinochet from power and have free presidential elections in 1989. This article describes the projections that the authors made for the results of the plebiscite from early returns.
Engel Goetz, Eduardo   +1 more
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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