Results 111 to 120 of about 426,189 (312)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Scholar and Educator: the 65th Anniversary of Iskander Izmailov

open access: yesЗолотоордынское обозрение
In December 2025, the academic community marks the 65th birthday of the outstanding historian and archaeologist, Doctor of Historical Sciences Iskander Lerunovich Izmailov. The jubilarian is a leading researcher at the M.A. Usmanov Center for Research on
Giniyatullina L.S.
doaj   +1 more source

Science and its Historicity

open access: yesTransversal: International Journal for the Historiography of Science, 2018
Book Review:Condé, Mauro L. “Um Papel para a História”: O Problema da Historicidade da Ciência. [“A role for the History”: The Problem of the Historicity of Science].
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

The Kent Historian, Newsletter of the Kent Historical Society, Issue 67, Fall 2009

open access: yes, 2009
THE KENT HISTORIAN Newsletter of the Kent Historical Society Fall 2009 Number Issue HISTORY FEATURE Beckwith Orchards Owned, Operated for Five Generations F or many, a visit to Beckwith Or­chards on Lake Rockwell Road in Franklin Township is much more ...

core  

WHO NEEDS THE HISTORICAL SCIENCE AND FOR WHAT?

open access: yesВысшее образование в России, 2016
This paper is the review of the monograph of prof. V.B. Chistyakov "Historical component in higher education" (Moscow: Moscow State Industrial University Publ., 2015), which addresses the topical problems of teaching history in higher school.
Vladislav F. Marukhin, Anatoliy I. Utkin
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Candidates for historical supernovae and their comparison against known Chinese records [PDF]

open access: yes, 2003
In this MSc thesis, possible/probable supernova remnants associated with possible/probable historical supernovae are discussed and advancements in knowledge surrounding possible remnants associated with historical supernovae older than about a thousand ...
Wilson, Graham Philip
core  

History of science in Science education : development and validation of a checklist for analysing the historical content of science textbooks

open access: yes, 2002
One of the aspects science education should focus on is learning about science. Achieving a good understanding of this aspect requires, among others, the use of the history of science.
Leite, Laurinda   +4 more
core   +1 more source

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