Results 181 to 190 of about 8,692,367 (346)

Ancient environmental genome reveals a migratory brown bear individual in Early Holocene Scandinavia. [PDF]

Proc Natl Acad Sci U S A
Johnson E, Feinauer IS, Regnéll C, Jin C, Chacón-Duque JC, Oteo-García G, Gyllencreutz R, Greenwood SL, Dalén L, Heintzman PD, Linderholm A.   +10 more
europepmc   +1 more source

Section L (Historical and Philological Sciences) [PDF]

Science, 1924
F E, Brasch, M H, Liddell, F G, Cottrell, H, Prentiss   +3 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Precipitation observing network gaps limit climate change impact assessment. [PDF]

Nature
Su J, Miao C, Zwiers F, Beck H, Jones P, Sun Q, Slater LJ, Berghuijs WR, Wada Y, Rosenfeld D, Gou J, Wu Y, Tarolli P, Borrelli P, Panagos P, Alexander LV, Zhang Q, Hu J, Min SK, Samaniego L, Duan Q, Destouni G, Marengo JA, Modarres R, Sorooshian S.   +24 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Machine learning helps to strongly reduce future warming uncertainty. [PDF]

Nat Commun
Li C, Wu J, Wang Z, Zwiers FW, Zhang X, Chen X.   +5 more
europepmc   +1 more source

Scientific literacy: Another look at its historical and contemporary meanings and its relationship to science education reform

, 2000
G. DeBoer
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Millennial land carbon emissions in China offset by carbon sinks of the past four decades. [PDF]

Nat Commun
Chen W, Ciais P, Yu K, Viovy N, Li S, Tan L.   +5 more
europepmc   +1 more source

Science, Agency and Ontology: A Historical-Materialist Response to New Materialism

, 2018
S. Choat
semanticscholar   +1 more source