Results 151 to 160 of about 1,885,281 (312)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Climate, peace, and conflict-past and present: Bridging insights from historical sciences and contemporary research. [PDF]

Ambio
White S, Collet D, Alcoberro A, Barriendos M, Brázdil R, Castell P, Chen S, de Coning C, Degroot D, Dolák L, Döring S, Gorostiza S, Kleemann K, Krampe F, Lin KH, Maughan N, Melo N, Molloy B, Ogilvie AEJ, Pai P, Pei Q, Pfister C, Serafimova S, Zhang D.   +23 more
europepmc   +1 more source

Historical understanding of science

, 2015
En este breve ensayo, el autor va explicando con algún detalle la formación de la ciencia a partir de la comprensión que la epistemología hace de ella. Recorre, sin embargo, solo cuatro momentos claves: su formación, la revolución moderna, el cientificismo del siglo XIX y finalmente, la comprensión realizada por la epistemología ...
openaire   +1 more source

Measurement in Economics and Social Science [PDF]

The paper discusses measurement, primarily in economics, from both analytical and historical perspectives. The historical section traces the commitment to ordinalism on the part of economic theorists from the doctrinal disputes between classical ...
Hillinger, Claude
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Utilizing large language models to construct a dataset of Württemberg's 19th-century fauna from historical records. [PDF]

PLoS One
Teich MC, Escobari B, Rehbein M.
europepmc   +1 more source

Nobel laureate Robert E. Lucas, Jr.; architect of modern macroeconomics [PDF]

In 1995, Robert E. Lucas, Jr., was awarded the Nobel Prize in Economic Sciences. This review places Lucas’ work in a historical context and evaluates the effect of this work on the economics profession.
V.V. Chari
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Strategies for updating rules driven by reinforcement learning to solve social dilemmas. [PDF]

PLoS One
Wang Y, Yu X, Lu S.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source