Results 141 to 150 of about 353,625 (313)

The EU Council Presidency Dilemma: an Historical Institutionalist Interpretation [PDF]

open access: yes
The aim of this article is to demonstrate the usefulness of taking into account the variable of EU institutional development when analysing the consequences of EU membership. Using an historical institutionalist perspective, the article examines the path
Ana Mar Fernàndez
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Europe, China and the ‘Family of Nations’: Paradoxes of the ‘Commercial’ Enlightenment during the Sattelzeit (1780-1840) [PDF]

open access: yes, 2015
Scholarship has explored to a certain extent how the Western representation of China changed between the end of the eighteenth and the beginning of the nineteenth century, until the eve of the Anglo-Chinese War of 1840-1842. The period 1780-1840 has been
ABBATTISTA, GUIDO
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Annual Report, Health Sciences Libraries, 2015/2016 [PDF]

open access: yes, 2016
In 2015/2016 we made our work visible through newly renovated spaces that support collaboration, learning, productivity, and study. We created new technology-enhanced spaces that support research and learning via our Virtual Reality Studio, Data ...
Health Sciences Libraries
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Comparative historical analysis in the social sciences [PDF]

open access: yes
This book systematically investigates the past accomplishments and future agendas of contemporary comparative-historical analysis. Its core essays explore three major issues: the accumulation of knowledge in the field over the past three decades, the ...

core  

The Kent Historian, Kent Historical Society Newsletter, Number 79, Spring 2013 [PDF]

open access: yes, 2013
THE KENT HISTORIAN The Newsletter of the Kent Historical Society Spring 2013 Number 79 Beloved, iconic Erie Depot gets a new roof Work has already begun to renew the exterior of the iconic Erie Depot on Franklin Avenue.

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Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

The importance of advanced physical and mathematical sciences to the Australian economy [PDF]

open access: yes, 2015
This report was commissioned by the Office of the Chief Scientist and the Australian Academy of Science and produced by the Centre for International Economics (CIE).
The Centre for International Economics
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