Results 151 to 160 of about 15,478,074 (304)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tualatin Plains Historical Society Meeting about Halloween

, 1979
An audio recording of a Tualatin Plains Historical Society meeting about participants' recollections and stories of ...

core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Climate, peace, and conflict-past and present: Bridging insights from historical sciences and contemporary research. [PDF]

Ambio
White S, Collet D, Alcoberro A, Barriendos M, Brázdil R, Castell P, Chen S, de Coning C, Degroot D, Dolák L, Döring S, Gorostiza S, Kleemann K, Krampe F, Lin KH, Maughan N, Melo N, Molloy B, Ogilvie AEJ, Pai P, Pei Q, Pfister C, Serafimova S, Zhang D.   +23 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Other title: Nature Trail

, 2012
application/pdf; "©2012 Kansas Historical Society."; Includes a map of the Kansas Historical Society grounds showing the Nature ...
Kansas State Historical Society.
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Paleogenomics retraces the ancient population history of Southwestern East Asia for the past 12 000 years. [PDF]

Natl Sci Rev
Bai F, Zhang X, Fu Y, Lu H, Li F, Bennett EA, Pei S, Cao P, Dai Q, Liu F, Feng X, Zhang M, Wang W, Li F, Zhang G, Ping W, Liu T, Fu Q.   +17 more
europepmc   +1 more source

Historical Medicine and Science [PDF]

Nature, 1942
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Kansas State Historical Society Annual Report, 2007

, 2008
The Kansas State Historical Society became the Kansas Historical Society, a state agency, in 2007. The Kansas State Historical Society, Inc.
Kansas Historical Society
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