Results 71 to 80 of about 1,885,281 (312)
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Transversal: International Journal for the Historiography of Science, 2018 Book Review:Condé, Mauro L. “Um Papel para a História”: O Problema da Historicidade da Ciência. [“A role for the History”: The Problem of the Historicity of Science].
openaire +3 more sources
100 years of Einstein's theory of Brownian motion: from pollen grains to protein trains [PDF]
, 2005 Experimental verification of the theoretical predictions made by Albert Einstein in his paper, published in 1905, on the molecular mechanisms of Brownian motion established the existence of atoms.
A Einstein +7 more
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Economics, Biology, and Culture: Hodgson on History [PDF]
, 2003 This book addresses what the author claims, with considerable justification, to be the foremost challenge confronting the social and behavioral sciences today: the problem of historical specificity.
Field, Alexander J.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Вig Data and Historical Social Science [PDF]
Sotsiologicheskie issledovaniya, 2015 “Big Data” can revolutionize historical social science if it arises from substantively important contexts and is oriented towards answering substantively important questions. Such data may be especially important for answering previously largely intractable questions about the timing and sequencing of events, and of event boundaries.
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Frontiers in SociologyIntroductionThis article addresses the pressing need to transform the teaching of History and Social Sciences by moving beyond traditional approaches centered on rote memorization and content reproduction.
Carmen Burgos-Videla +2 more
doaj +1 more source