Results 111 to 120 of about 432,891 (284)

Geoff Hodgson on pluralism and historical specificity [PDF]

open access: yes, 2019
Geoff Hodgson has made a variety of innovative contributions to thinking about the methodology of economics. Here two particular contributions are considered together: his advocacy of pluralism at different levels and his concern with historical specificity. We first explore his argument for specificity in terms of a pluralist ontology.
openaire   +2 more sources

Some Legacies of Robbins'Nature and Signifance of Economic Science [PDF]

open access: yes
The Abstract of your paper: This paper criticises three Robbinsian positions still often found in modern economics: (1) the methodology of intuitively obvious assumptions; (2) treating facts as illustrations rather than as tests of theoretical ...
Richard Lipsey
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Dialysate cyclophilin A as a predictive marker for historical peritonitis in patients undergoing peritoneal dialysis

open access: yesHeliyon
Introduction: No markers have been used to diagnose historical peritoneal dialysis (PD)-related peritonitis. Cyclophilin A (CypA) is associated with glucose toxicity and inflammation.
Shang-Feng Tsai   +3 more
doaj   +1 more source

ACTUALIZATION OF THE ZONE OF PROXIMAL DEVELOPMENT OF JUNIOR SCHOOLCHILDREN WITH MENTAL RETARDATION BY MEANS OF A LITERARY GAME [PDF]

open access: yesKrymskij Naučnyj Vestnik, 2017
The article discusses the concept of "zone of proximal development" from the standpoint of the cultural-historical approach, raises the problem of specificity of this concept in the modern system of education, justifies the use of literary games as an ...
M.E. Starostina, D.A. Starostin
doaj  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Unemployment out of nowhere – a structural axiomatic analysis of objective determinants [PDF]

open access: yes
Unemployment is usually explained with reference to the equilibrium of supply and demand in the labour market. This approach rests on specific behavioral assumptions that are formally expressed as axioms.
Kakarot-Handtke, Egmont
core   +1 more source

Validation of a Clinical Scoring System for Outcome Prediction in Dogs with Acute Kidney Injury Managed by Hemodialysis. [PDF]

open access: yes, 2016
BackgroundA scoring system for outcome prediction in dogs with acute kidney injury (AKI) recently has been developed but has not been validated.HypothesisThe scoring system previously developed for outcome prediction will accurately predict outcome in a ...
Cowgill, LD   +4 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

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