Results 61 to 70 of about 9,797,833 (343)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Development of Evernoted Learning Media Center as Learning Innovation and Assistive Technology for People with Disabilities

Jurnal Teknologi Pendidikan
The development of Evernoted Learning Media Center aims to introduce inclusive learning innovations for people with disabilities. This study presents the design and implementation of an Evernoted-based learning platform with accessibility features ...
Riski Agung Novarianto, Prihma Utami, Ferdinan Bashofi, Septa Rahadian, Puspita Pebri Setiani, Faizah Ulumi Firdausi, Nurcholis Sunuyeko   +6 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

PENDIDIKAN SEJARAH, SEBUAH TINJUAN METODOLOGI

Cendekia: Jurnal Pendidikan dan Pembelajaran, 2015
This paper presents conceptual description on historical education  in the methods of historical discovery using library analyses.  The analyses indicate that (1) historical events can be described through two empirical facts: written and oral ...
Dita Hendriani
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Histories of entrepreneurship education

Management & Organizational History
Entrepreneurship education often appears as a recent innovation shaped by contemporary challenges or zeitgeist. Historical evidence, however, shows it has deeper roots and greater complexity than commonly assumed. This special issue adopts a ‘marketplace’ metaphor to show how supply-push (academic initiatives and pedagogical innovations) and demand ...
Christian Stutz, Anders Ravn Sørensen, Christoph Viebig   +2 more
openaire   +3 more sources

‘I Saw Angry People and Broken Statues’: Historical Empathy in Secondary History Education

, 2017
Tasks which invite students to identify with historical actors and describe their perspectives are a common phenomenon in history education. The aim of this study is to explore the differences in students’ answers when completing a writing task in first ...
Tessa de Leur, Carla A. M. van Boxtel, A. Wilschut   +2 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

“Their definition of rigor is different than ours”: The promise and challenge of enactivist pedagogies in the social studies classroom

Cogent Education, 2016
The theoretical justification for enactivist approaches to learning is just beginning to emerge, and remains largely theoretical. Enactivism conceptualized as play beings us closer to the heart of the question about how play-based social studies might ...
Cory Wright-Maley
doaj   +1 more source