Results 51 to 60 of about 1,795,481 (218)
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Peripheral corridors: the post-metropolitan landscape of Leganes (Madrid) and Melville (Johannesburg) [PDF]
, 2019 The file attached to this record is the author's final peer reviewed versionThesis describing main arguments: This paper consists of a general history of the concept of periphery and aims to introduce the different definitions of periphery in ...
Hendricks, Denver, Martinez Perez, Alona
core
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Willi Graf of the White Rose: Transformation of an Image (poster session) [PDF]
, 2011 My dissertation focuses on Willi Graf of the student resistance group called the White Rose. While the history of the White Rose is well known in Germany and possibly Europe in general, Willi Graf’s story and significant contribution to the group is ...
Richards-Wilson, Stephani
core +1 more source
Primary prevention of beta-cell autoimmunity and type 1 diabetes - The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives. [PDF]
, 2016 OBJECTIVE: Type 1 diabetes can be identified by the presence of beta-cell autoantibodies that often arise in the first few years of life. The purpose of this perspective is to present the case for primary prevention of beta-cell autoimmunity and to ...
Agiostratidou, G +8 more
core +4 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Psychological care of women with a family history of breast cancer [PDF]
, 2005 In parallel to the development of clinical cancer genetics services for women with a significant history of breast cancer, there has been a growing need to identify the psychological sequelae to risk ascertainment, predictive genetic testing and ...
Hopwood, Penelope
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source