Results 51 to 60 of about 2,099,771 (306)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Buffon, Jefferson and the theory of New World degeneracy

Evolution: Education and Outreach, 2019
In his magnum opus, Natural History: General and Particular, Count Buffon, one of the leading natural historians of the 18th century, argued that all life in the New World, particularly North America, was degenerate—weaker, smaller and feebler—than life ...
Lee Alan Dugatkin
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

New Directions in the History of Written Culture

Culture & History Digital Journal, 2012
This article reviews some new directions in the history of writing practices, concentrating on Western Europe and the Americas in the nineteenth and early twentieth centuries.
Martyn Lyons
doaj   +1 more source

Text types in a new medium : the first newspapers (1609) [PDF]

, 2009
The first printed newspapers in the modern sense of the word appeared in the seventeenth century. They were weekly publications which contained regular reports by correspondents from all over Europe, mainlyon political matters. Although the new medium as
Fritz, Gerd
core  

Comparative historical sociology and the State : problems of method [PDF]

, 2016
Historical sociology can be understood both as a specific sub-field of sociology and as providing general conceptual underpinnings of the discipline, to the extent that it provides an understanding of the specificity of the modern state and the perceived
Anderson D, Arjomand SA, Bhambra GK, Bruun HH, Dunbar-Ortiz R, Eisenstadt SN, Elkins C, Gurminder K. Bhambra, Holmwood J, Kalberg S, Knöbl W, Mommsen WJ, Mommsen WJ, Moore B, Poggi G, Tilly C, Wagner P, Wallerstein I, Weber M, Wolin SS   +19 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Hacia una historiografía de la enfermedad: Prácticas, profesiones y enfermos

Memoria y Civilización, 2008
The article considers the development of the history of medicine since its institutionalization, in 19th century Europe. The historiographical tendencies that conditioned this development of the branch of learning are analysed.
Pilar León Sanz
doaj  

May 1968 Protests in France in the Collective Memory of the European Commission Politicians

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The May 1968 protests are an important place of remembrance in the history of Europe. Methods and materials. The author uses the methods of studying collective memory to analyze the image of the May protests in the collective memory ...
Nikita Bulavintsev
doaj   +1 more source