Results 51 to 60 of about 434,558 (341)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
BMC Health Services Research, 2009 Background Coronary heart disease (CHD) is the leading cause of death in the developed world, and its prevention a core activity in current UK general practice.
Kai Joe +8 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Buffon, Jefferson and the theory of New World degeneracy
Evolution: Education and Outreach, 2019 In his magnum opus, Natural History: General and Particular, Count Buffon, one of the leading natural historians of the 18th century, argued that all life in the New World, particularly North America, was degenerate—weaker, smaller and feebler—than life ...
Lee Alan Dugatkin
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
New Directions in the History of Written Culture
Culture & History Digital Journal, 2012 This article reviews some new directions in the history of writing practices, concentrating on Western Europe and the Americas in the nineteenth and early twentieth centuries.
Martyn Lyons
doaj +1 more source
A Short History of Urban Forestry in Europe
Arboriculture & Urban Forestry, 1997 In Europe, more attention is being given to the concept of urban forestry. However, it is applied more to forests under a strong urban influence than to urban greenspace at large.
C. Konijnendijk
semanticscholar +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
May 1968 Protests in France in the Collective Memory of the European Commission Politicians
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношенияIntroduction. The May 1968 protests are an important place of remembrance in the history of Europe. Methods and materials. The author uses the methods of studying collective memory to analyze the image of the May protests in the collective memory ...
Nikita Bulavintsev
doaj +1 more source