Results 61 to 70 of about 14,662,649 (307)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Transformation of History Education Based on Local Wisdom to Foster Historical Awareness in Generation Z

Jurnal Iqra': Kajian Ilmu Pendidikan
This research aims to analyze the transformation of history learning based on local wisdom in fostering historical awareness in generation Z at MA Matik Al Uswah Banyuwangi.
Agus Mursidi
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Implementasi Berpikir Historis dalam Pembelajaran Sejarah di SMA Negeri 8 dan SMA Negeri 10 Samarinda

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
Historical thinking is a competency that students must master in history learning. This study focuses on the first competency, diachronic (chronological) thinking.
Muhammad Ilham Syahputra, Hieronymus Purwanta, Djono   +2 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Ohio History Center Groundbreaking photographs

, 1966
Governor James Rhodes used an Ohio-shaped shovel to turn the first earth for the new Ohio History Center, shown here on on August 22, 1966. The Ohio Historical Society (now the Ohio History Connection) moved to the new building, located near the Ohio ...
Ohio History Connection
core  

Foundations of U.S. History: Virginia History as U.S. History

, 2009
The WARC file must be opened using a program like Webrecorder.io. The ZIP contains a static version of the website.Foundations of U.S. History: Virginia History as American History was a Teaching American History grant, funded by the U.S.
Loudon County Public Schools, RRCHNM, /, GMU Department of History and Art History, Various   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Children on steps of Ohio History Center

, 1970
This photograph of children on the steps of the Ohio History Center was taken around 1970. At a press conference held in November 10, 1964, Governor James Rhodes announced financing for the construction of a new archives, library, and museum building ...
Ohio History Connection
core