Results 101 to 110 of about 4,206,396 (342)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

21st Century Ergonomic Education, From Little e to Big E [PDF]

open access: yes, 2014
Despite intense efforts, contemporary educational systems are not enabling individuals to function optimally in modern society. The main reason is that reformers are trying to improve systems that are not designed to take advantage of the centuries of ...
Barsky, Constance K.   +1 more
core  

Federalism in Middle Europe: a model for a future European education system? [PDF]

open access: yes, 2001
The article discusses the principle of federalism as a potential institutional principle of the future education system in Europe. It reminds of the strengths and weaknesses of federalism in the history of Central Europe and clarifies the differences ...
Waterkamp, Dietmar
core   +1 more source

Business Activity in Mediterranean Sea and its Impact on Crusades Emirates in Levant Country fell during the second half of seventh century(A.H.)

open access: yesالأستاذ, 2018
       The commercial activity in the Mediterranean had a major impact in Emirates Crusades in Levant country fell by Al- Mamluks hand , however , the competition was at its peak between the European Emirates particularly among Italian republics marine ,
Dr.Nihad Hameed ELaibi Aged   +1 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

International Centre for the Study of Historical consciousness [PDF]

open access: yes, 2020
My social studies education friend thought I had proposed a program of “history awareness.” My graduate student feared I was setting myself up in competition with Hayden White’s History of Consciousness program.
Seixas, Peter
core   +1 more source

Overcoming Challenges of Teaching Earth History Classes for Teachers in a Rock-free, Urban Environment [PDF]

open access: yes, 2004
Instructing university-level Earth history to future teachers is made all the more difficult when it is being done in an urban environment devoid of any local rock outcroppings.

core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

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