Results 51 to 60 of about 156,592 (295)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A revisited history of cacao domestication in pre-Columbian times revealed by archaeogenomic approaches

Scientific Reports
Humans have a long history of transporting and trading plants, contributing to the evolution of domesticated plants. Theobroma cacao originated in the Neotropics from South America.
Claire Lanaud, Hélène Vignes, José Utge, Gilles Valette, Bénédicte Rhoné, Mariella Garcia Caputi, Natalia Sofía Angarita Nieto, Olivier Fouet, Nilesh Gaikwad, Sonia Zarrillo, Terry G. Powis, Ann Cyphers, Francisco Valdez, S. Quirino Olivera Nunez, Camilla Speller, Michael Blake, Fred Jr. Valdez, Scott Raymond, Sarah M. Rowe, Guy S. Duke, Francisco Ernesto Romano, Rey Gaston Loor Solórzano, Xavier Argout   +22 more
doaj   +1 more source

The Crab Hole Mosquito Blues

Emerging Infectious Diseases, 2011
Venezuelan equine encephalomyelitis (VEE) epizoodemics were reported at 6–10-year intervals in northern South America beginning in the 1920s. In 1937, epizootic VEE virus was isolated from infected horse brain and shown as distinct from the North ...
Karl M. Johnson, Douglas F. Antczak, William H. Dietz, David H. Martin, Thomas E. Walton   +4 more
doaj   +1 more source

The Wai Wai Indians of South America: history and genetics

Annals of Human Biology, 1996
Demographic medical and genetic information was obtained in a population of Carib-speaking Wai Wai Indians living in northern Brazil. At present mortality is low and fertility moderate, with a low variance in offspring number in completed families. Mobility is high, but about two-thirds of the unions are endogamic.
S M, Callegari-Jacques, F M, Salzano, T A, Weimer, M H, Franco, M A, Mestriner, M H, Hutz, L, Schüler   +6 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Archaeometric Study of Iron Age Pottery Production in Central Sicily: A Case of Technological Conservatism

Open Archaeology
This study presents an in-depth archaeometric investigation of Iron Age ceramic assemblage dating from 950 to 750 BCE from the sanctuary at Polizzello Mountain, Sicily.
Tanasi Davide, Levi Sara Tiziana, Caso Gianpiero, Tykot Robert H., Greco Enrico   +4 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

South Korea is the center for the origin and emanation of soybean mosaic virus with Bayesian phylogeographic inference

Microbiology Spectrum
Soybean mosaic virus (SMV) is one of the most serious viral pathogens, causing reductions in soybean yield worldwide. Using more than 350 time-stamped SMV coat protein encoding gene sequences from more than a dozen countries and regions in Central Asia ...
Shiqing Wei, Lei Zhang, Liang Cheng, Linwen Liu, Guoliang Chen, Hui Yang, Xiaoyan Qiu, Liya Luo, Guoshu Gong, Min Zhang   +9 more
doaj   +1 more source

Female Gothic, Modernity and the Aesthetics of Change: Demythologising the South in Eudora Welty

Journal of Contemporary Poetics, 2023
Eudora Welty, an American fiction writer, brings forth women’s issues and promotes feminist ethics in her writings: novels and short stories. Her stories reveal her concern with the extended subordination of women under machismo in Southern America ...
Shabbir Ahmad, Khadija Khalid, Azra Khanam   +2 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source