Results 61 to 70 of about 1,694,874 (301)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2022 Yellow fever virus (YFV) has a long history of impacting human health in South America. Mayaro virus (MAYV) is an emerging arbovirus of public health concern in the Neotropics and its full impact is yet unknown. Both YFV and MAYV are primarily maintained
Michael Celone +5 more
doaj +1 more source
Marine Flora and Fauna of the Northeastern United States Echinodermata: Crinoidea [PDF]
, 1990 The crinoid fauna of the continental margin (0-1500 m) of northeastern North America (Georgia to Canada) includes 14 species in 13 genera and 5 families. We introduce the external morphology and natural history of crinoids and include a glossary of terms,
Dearborn, John H., Messing, Charles G.
core +1 more source
The endemic gastropod fauna of Lake Titicaca : correlation between molecular evolution and hydrographic history [PDF]
, 2012 Lake Titicaca, situated in the Altiplano high plateau, is the only ancient lake in South America. This 2- to 3-My-old (where My is million years) water body has had a complex history that included at least five major hydrological phases during the ...
Albrecht, Christian +7 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Pictured Politics: Visualizing Colonial History in South American Civic Portrait Collections [PDF]
, 2013 poster abstractThis presentation addresses the history of institutional art collecting in Spanish colonial South America. In viceregal South America, political changes inspired adjustments to pictorial convention in portraits, imbuing portraiture with a ...
Engel, Emily A.
core
Prevalence of and Factors Associated with Negative Microscopic Diagnosis of Cutaneous Leishmaniasis in Rural Peru. [PDF]
, 2018 Cutaneous leishmaniasis is endemic to South America where diagnosis is most commonly conducted via microscopy. Patients with suspected leishmaniasis were referred for enrollment by the Ministry of Health (MoH) in Lima, Iquitos, Puerto Maldonado, and ...
Alves, Clark +12 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The changing course of the Amazon River in the Neogene: center stage for Neotropical diversification
Neotropical Ichthyology, 2018 We review geological evidence on the origin of the modern transcontinental Amazon River, and the paleogeographic history of riverine connections among the principal sedimentary basins of northern South America through the Neogene.
James S. Albert, Pedro Val, Carina Hoorn
doaj +1 more source
A Invenção do Rio Amazonas na Cartografia (1540-1560)
Terra Brasilis, 2020 This article seeks to explore the process of inventing the Amazon River on world and regional maps after the Castilian expedition of Francisco de Orellana (1541-1542), who sailed almost the entire river course.
Lucas Montalvão Rabelo
doaj +1 more source