Results 31 to 40 of about 2,119,900 (290)

El conflicto armado colombiano visto por los escolares

open access: yesClio y Asociados, 2020
The present paper analyzes some studies that address the Colombian armed conflict of recent decades, from the imaginary and representations of students in basic education, under the assumption that this view allows to ...
Diego Arias Gómez
doaj   +1 more source

The Turbulent Sixties at Rutgers: An Interview with Richard P. McCormick

open access: yes, 1997
Richard P. McCormick’s professional life has been so intertwined with Rutgers University’s history that it is difficult to imagine anyone who knows more about Rutgers or who has put a greater imprint on the institution.
Birkner, Michael J.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Para uma definição de Didática da História Towards a history didactics definition

open access: yesRevista Brasileira de História, 2008
Este artigo visa definir a Didática da História de acordo com a atual bibliografia alemã, que a considera mais próxima da História do que da Educação. Associada à palavra Geschichtsdidaktik, essa definição se opõe aos conceitos de Didática da História ...
Oldimar Cardoso
doaj   +1 more source

Educating in History: Thinking Historically through Historical Reenactment

open access: yesSocial Sciences, 2022
This paper aimed to identify trends in the scientific literature that relate the link between two concepts: historical thinking and historical reenactment. The definition of both concepts and their commonalities were examined.
José-Manuel González-González   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Digital games based learning for history – problem solving or problematic?

open access: yesEducation in the North, 2021
This study follows the design and development of an educational digital game, Tales of Iona, which was designed to be used to promote understanding of the ancient Scottish island of Iona in upper primary or early secondary schools.
Katrina Foy
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The Hungarian National Minority in Slovenia: Assessment of Protection and Integration after EU Accession [PDF]

open access: yesRomanian Journal of European Affairs, 2013
The following paper will focus on the issue of the Hungarian minority protection in Slovenia. The first section introduces the Hungarian national minority, its main features and historical evolution.
Sigrid Lipott
doaj  

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