Results 81 to 90 of about 2,271,562 (311)

Erosive Hit-and-Run Impact Events: Debris Unbound

, 2015
Erosive collisions among planetary embryos in the inner solar system can lead to multiple remnant bodies, varied in mass, composition and residual velocity. Some of the smaller, unbound debris may become available to seed the main asteroid belt.
Leinhardt, Zoe M., Sarid, Gal, Stewart, Sarah T.   +2 more
core   +1 more source

Clonal expansion of second-hit cells with somatic recombinations or C>T transitions form porokeratosis in MVD or MVK mutant heterozygotes.

Journal of Investigative Dermatology, 2019
Patients with disseminated superficial actinic porokeratosis (DSAP) and linear porokeratosis exhibit monoallelic germline mutations in genes encoding mevalonate pathway enzymes, MVD or MVK.
A. Kubo, Takashi Sasaki, Hisato Suzuki, A. Shiohama, S. Aoki, Showbu Sato, Harumi Fujita, N. Ono, N. Umegaki-Arao, T. Kawai, K. Nakabayashi, K. Hata, D. Yamada, Y. Matsubara, K. Kosaki, M. Amagai   +15 more
semanticscholar   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Towards a Common Research Strategic Roadmap for the Transportation Sector in Europe and beyond [PDF]

Journal of Systemics, Cybernetics and Informatics, 2013
DETRA (Developing a European Transport Research Alliance) is a 7th Framework project, whose concept derived from the so-called Lyon Declaration and concerns the deepening of the European Research Area objectives in transport in order to address the Grand
Evangelos Bekiaris, Matina Loukea, Steve Phillips, Wolfgang Steinicke   +3 more
doaj  

Randomized SMILES strings improve the quality of molecular generative models

Journal of Cheminformatics, 2019
Recurrent Neural Networks (RNNs) trained with a set of molecules represented as unique (canonical) SMILES strings, have shown the capacity to create large chemical spaces of valid and meaningful structures.
Josep Arús-Pous, Simon Viet Johansson, Oleksii Prykhodko, Esben Jannik Bjerrum, Christian Tyrchan, Jean-Louis Reymond, Hongming Chen, Ola Engkvist   +7 more
doaj   +1 more source

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Nature Communications, 2022
aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and ...
Xinyan Zhu, Yu Qian, Xiaowan Li, Zhenmei Xu, Ruixue Xia, Na Wang, Jiale Liang, Han Yin, Anqi Zhang, Changyou Guo, Guangfu Wang, Yuanzheng He   +11 more
doaj   +1 more source

Fate of the runner in hit-and-run collisions [PDF]

, 2019
In similar-sized planetary collisions, a significant part of the impactor often misses the target and continues downrange. We follow the dynamical evolution of "runners" from giant impacts to determine their ultimate fate. Surprisingly, runners re-impact
Asphaug, Erik, Emsenhuber, Alexandre
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening

SLAS Discovery
Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds.
Alice Lanne, Catherine Bardelle, Gareth Davies, Antonia Turberville, Hannah Semple, Rachel Moore, Geoffrey A. Holdgate   +6 more
doaj   +1 more source