Results 71 to 80 of about 498,175 (297)

Optimization of HIT solar cell [PDF]

, 2022
La tesi svolta tratta le tematiche relative all’ottimizzazione di celle solari HIT (celle solari aventi un sottile strato di conduttore intrinseco). Tali celle sono caratterizzate da un’eterogiunzione tra silicio amorfo e cristallino; grazie a tale ...
Corazza, Michael
core  

Towards a call for transformative practices in academia enhanced by generative AI

EURODL
In the present paper, we explore the integration of Generative Artificial Intelligence (GenAI) into the teaching, learning and research practices within the Faculty of Instructional Technologies undergraduate programme at the Holon Institute of ...
Dan Kohen-Vacs, Meital Amzalag, Hayley Weigelt-Marom, Lilach Gal, Omri Kahana, Nohar Raz-Fogel, Oren Ben-Aharon, Noga Reznik, Moti Elnekave, Maya Usher   +9 more
doaj   +1 more source

A novel method for the detection of R-peaks in ECG based on K-Nearest Neighbors and Particle Swarm Optimization

EURASIP Journal on Advances in Signal Processing, 2017
Cardiovascular diseases are associated with high morbidity and mortality. However, it is still a challenge to diagnose them accurately and efficiently. Electrocardiogram (ECG), a bioelectrical signal of the heart, provides crucial information about the ...
Runnan He, Kuanquan Wang, Qince Li, Yongfeng Yuan, Na Zhao, Yang Liu, Henggui Zhang   +6 more
doaj   +1 more source

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Nature Communications, 2022
aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and ...
Xinyan Zhu, Yu Qian, Xiaowan Li, Zhenmei Xu, Ruixue Xia, Na Wang, Jiale Liang, Han Yin, Anqi Zhang, Changyou Guo, Guangfu Wang, Yuanzheng He   +11 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source