Results 71 to 80 of about 440,240 (309)

Cartesian Impedance Control on Five-Finger Dexterous Robot Hand DLR-HIT II with Flexible Joint

, 2010
This paper presents an impedance controller for five-finger dexterous robot hand DLR-HIT II, which is derived in Cartesian space. By considering flexibility in finger joints and strong mechanical couplings in differential gear-box, modeling and control ...
Hong Liu, Zhaopeng Chen, Minghe Jin, Lii, Neal Y., Shaowei Fan, Chen, Zhaopeng, Jin, Minghe, Fan, Shaowei, Liu, Hong, Neal Y. Lii   +9 more
core   +1 more source

Randomized SMILES strings improve the quality of molecular generative models

Journal of Cheminformatics, 2019
Recurrent Neural Networks (RNNs) trained with a set of molecules represented as unique (canonical) SMILES strings, have shown the capacity to create large chemical spaces of valid and meaningful structures.
Josep Arús-Pous, Simon Viet Johansson, Oleksii Prykhodko, Esben Jannik Bjerrum, Christian Tyrchan, Jean-Louis Reymond, Hongming Chen, Ola Engkvist   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

HIT-ISOseq paper

HIT-ISOseq paper Supplementary Data and relevant ...
zhuoxing shi (18451083)
core   +1 more source

POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening

SLAS Discovery
Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds.
Alice Lanne, Catherine Bardelle, Gareth Davies, Antonia Turberville, Hannah Semple, Rachel Moore, Geoffrey A. Holdgate   +6 more
doaj   +1 more source

A Hit, a Hit—A Very Palpable Hit: Mild TBI and the Development of Epilepsy [PDF]

Epilepsy Currents, 2019
[Box: see text]
openaire   +2 more sources

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

A hit és a turizmus kapcsolatának vizsgálata Szabolcs-Szatmár-Bereg megye vallási kirándulói körében

, 2020
Dolgozatomban a hit és a turizmus kapcsolatát vizsgálom Szabolcs-Szatmár-Bereg megye vallási kirándulói körében. Bemutatom a vallási turizmust és kialakulását, a legismertebb kegyhelyeket Magyarországon és külföldön.
Zatykó Ferencné Csépke, Ildikó
core  

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding

, 2021
Computational approaches in drug discovery and development hold great promise, with artificial intelligence methods undergoing widespread contemporary use, but the experimental validation of these new approaches is frequently inadequate.
Uta, Lessel, Kristina, Edfeldt, Matthew H., Todd, John J., Irwin, Benjamin G. , Perry, Cora, Scholten, Ingo, Muegge, Ulrich A.K., Betz, Michael K., Gilson, Andrea, Volkamer, Johanna M. , Jansen, Rommie E., Amaro, Ian, Dunham, Kumar Singh, Saikatendu, Matthieu, Schapira, Cheryl H., Arrowsmith, John, Moult, Aled M., Edwards, John D., Chodera, Wendy D., Cornell, Timothy M. , Willson, Gerhard, Hessler, Cristian G., Bologa, Claudia R., Gordijo, Andrew R., Leach, Daniel, Kuhn, Anders, Hogner, Gerhard F., Ecker, Rima, Al-awar, Yoshua, Bengio, Tudor I., Oprea, Patrick, Riley, Suzanne, Ackloo, Hatylas, Azevedo, Alexander, Hillisch, Alpha A., Lee, Vijayaratnam, Santhakumar, Robert A., Batey, Masoud, Vedadi   +38 more
core   +1 more source

Call for Submissions - Special Issue July 2019: The Role of Technology and Innovation in Patient Experience

Patient Experience Journal, 2018
Patient Experience Journal (PXJ) is excited to announce the call for submissions for its July 2019 special issue on the topic of the role of technology in patient & family experience.
Patient Experience Journal
doaj