Results 61 to 70 of about 440,240 (309)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A hit és az egészség összefüggésének vizsgálata
, 2020 Szakdolgozatomban a hit és egészség összefüggésének vizsgálatával foglalkozom. Egyre több tudományos kutatás bizonyítja, azt a tényt, hogy igenis létezik egy kapcsolat a hit és az egészség, a lélek és a test között.
Endreffy, Mária
core
, 1959 Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about a fatal hit-and-run accident in ...
WBAP-TV (Television station : Fort Worth, Tex.)
core +1 more source
Towards a call for transformative practices in academia enhanced by generative AI
EURODLIn the present paper, we explore the integration of Generative Artificial Intelligence (GenAI) into the teaching, learning and research practices within the Faculty of Instructional Technologies undergraduate programme at the Holon Institute of ...
Dan Kohen-Vacs +9 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tettere studentoppfølging? : undervegsrapport fra et HiT-internt prosjekt [PDF]
, 2004 Kvalitetsreformen i høyere utdanning har krav om tettere oppfølging av studentene, men sier ikke så mye om hvordan dette skal kunne gjennomføres i praksis, f.eks. i et emne med mer enn 150 aktive studenter og én (1) foreleser/undervisningsperson. I dette
Istad, Roy M.
core
Towards a Common Research Strategic Roadmap for the Transportation Sector in Europe and beyond [PDF]
Journal of Systemics, Cybernetics and Informatics, 2013 DETRA (Developing a European Transport Research Alliance) is a 7th Framework project, whose concept derived from the so-called Lyon Declaration and concerns the deepening of the European Research Area objectives in transport in order to address the Grand
Evangelos Bekiaris +3 more
doaj
EURASIP Journal on Advances in Signal Processing, 2017 Cardiovascular diseases are associated with high morbidity and mortality. However, it is still a challenge to diagnose them accurately and efficiently. Electrocardiogram (ECG), a bioelectrical signal of the heart, provides crucial information about the ...
Runnan He +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source