Results 41 to 50 of about 440,240 (309)

Immune paradoxes of vaccine-induced thrombotic thrombocytopenia (VITТ), heparin-induced thrombocytopenia (HIT) and thrombosis: from general mechanisms to the unique VITТ and HIT course

Акушерство, гинекология и репродукция
Aim: to carry out a comparative analysis of the pathogenesis, clinical manifestations, diagnostic criteria as well as therapeutic strategies of vaccine-induced thrombotic thrombocytopenia (VITТ) and heparin-induced thrombocytopenia (HIT), two rare but ...
A. D. Makatsariya, S. V. Akinshina, A. V. Vorobev, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, N. A. Makatsariya, I. S. Kalashnikova, N. R. Gashimova, K. N. Grigoreva, I. A. Stepanov, I. M. Dikareva, A. Yu. Tatarintseva, A. V. Lazarchuk, A. R. Khisamieva, D. V. Blinov, P. Van Dreden, J.-Ch. Gris, I. Elalamy, G. Gerotziafas   +19 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Optimization of HIT solar cell [PDF]

, 2022
La tesi svolta tratta le tematiche relative all’ottimizzazione di celle solari HIT (celle solari aventi un sottile strato di conduttore intrinseco). Tali celle sono caratterizzate da un’eterogiunzione tra silicio amorfo e cristallino; grazie a tale ...
Corazza, Michael
core  

Change management and adoption of health information technology (HIT)/eHealth in public hospitals in Ghana: A qualitative study [PDF]

, 2022
In Ghana, as with other developing countries, there are several health information technology (HIT) initiatives as interventions to improve healthcare delivery. HIT implementation undoubtedly results in change.
Soar, Jeffrey, Yusif, Salifu, Hafeez-Baig, Abdul   +2 more
core   +1 more source

A de novo molecular generation method using latent vector based generative adversarial network

Journal of Cheminformatics, 2019
Deep learning methods applied to drug discovery have been used to generate novel structures. In this study, we propose a new deep learning architecture, LatentGAN, which combines an autoencoder and a generative adversarial neural network for de novo ...
Oleksii Prykhodko, Simon Viet Johansson, Panagiotis-Christos Kotsias, Josep Arús-Pous, Esben Jannik Bjerrum, Ola Engkvist, Hongming Chen   +6 more
doaj   +1 more source

Hitting the Romans

CoRR, 2023
Roman domination is one of few examples where the related extension problem is polynomial-time solvable even if the original decision problem is NP-complete. This is interesting, as it allows to establish polynomial-delay enumeration algorithms for finding minimal Roman dominating functions, while it is open for more than four decades if all minimal ...
Henning Fernau, Kevin Mann
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Methodology paper: a novel phantom setup for commissioning of scanned ion beam delivery and TPS

Radiation Oncology, 2019
Background Commissioning of treatment planning systems (TPS) and beam delivery for scanned light ion beams is an important quality assurance task. This requires measurement of large sets of high quality dosimetric data in anthropomorphic phantoms to ...
O. Jäkel, B. Ackermann, S. Ecker, M. Ellerbrock, P. Heeg, K. Henkner, M. Winter   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source