Results 31 to 40 of about 440,240 (309)
STOPLIGHT: A Hit Scoring Calculator
, 2023 We introduce STOPLIGHT, a web portal to assist medicinal chemists in prioritizing hits from screening campaigns and selection of compounds for optimization.
Konstantin, Popov +8 more
core +1 more source
Theory progress and applications of dielectric elastomers
International Journal of Smart and Nano Materials, 2013 This paper summarizes the research progress of dielectric elastomer (DE) and its composite materials, including the introduction of materials, theoretical research development, and typical applications.
Liwu Liu, Yanju Liu, Jinsong Leng
doaj +1 more source
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
Affective ScienceAbstract Neuroimaging of recognition memory reveals that the striatum responds more strongly to Hits (encoded stimuli recognized as old) vs. Correct Rejections (CRs: lures recognized as new), possibly because remembering old items is rewarding.
Arkadiy L. Maksimovskiy +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
International Journal of Smart and Nano Materials, 2016 The deployable structures based on shape memory polymer composites (SMPCs) have been developed for its unique properties, such as high reliability, low-cost, lightweight, and self-deployment without complex mechanical devices compared with traditional ...
Fengfeng Li +6 more
doaj +1 more source
AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning
Journal of Cheminformatics, 2020 We present the open-source AiZynthFinder software that can be readily used in retrosynthetic planning. The algorithm is based on a Monte Carlo tree search that recursively breaks down a molecule to purchasable precursors.
Samuel Genheden +5 more
doaj +1 more source
Design and motion analysis of a frog-like jumping robot based on a soft body detonation drive
Materials & Design, 2023 Inspired by the instantaneous power of the hindlimbs of frogs and the dexterous posture adjustment of their forelimbs, a frog-like jumping robot based on a soft body detonation drive was designed. By combining the flexibility of silicone material and the
Yitao Pan +5 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The Spotify Audio Features Hit Predictor Dataset (1960-2019)
, 2020 This is a dataset consisting of features for tracks fetched using Spotify's Web API. The tracks are labeled '1' or '0' ('Hit' or 'Flop') depending on some criterias of the author.
Ansari, F. (Farooq)
core +1 more source