Results 31 to 40 of about 686,994 (265)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Representations of the Metaverse in the Works of Potter Jason Walker

open access: yesالاكاديمي, 2023
The current research studies (representations of metaphysics in the works of potter Jason Walker) a concept that refers to To a large extent, by conveying a sense of reality to the recipient by conveying ideas, contents, and connotations.
Mayada Hassan Merhej
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ydLiu-HIT/deSALT: deSALT-v1.5.1

open access: yes, 2019
Bugfix: zero-length operation ...
ydliu, ydLiu-HIT, JiangTao
core   +1 more source

Comprehensive Validation of RANS-Based Urban Wind Flow Simulations using the ‘Michel-Stadt’ Benchmark

open access: yesJournal of Studies in Civil Engineering
Wind comfort analyses and the evaluation of locations for efficient small-scale wind turbines rely heavily on the accurate prediction of turbulent wind fields in urban environments.
Mushfiq Al Arafa, Amira Zinat
doaj   +1 more source

Interrelationship between daily COVID-19 cases and average temperature as well as relative humidity in Germany

open access: yesScientific Reports, 2021
COVID-19 pandemic continues to obstruct social lives and the world economy other than questioning the healthcare capacity of many countries. Weather components recently came to notice as the northern hemisphere was hit by escalated incidence in winter ...
Naleen Chaminda Ganegoda   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Dispersion-managed soliton fiber laser with random dispersion, multiphoton absorption and gain dispersion

open access: yes, 2018
We address the generation and interaction of dispersion-managed dissipative solitons (DMDS) in a model of fiber lasers with the cubic-quintic nonlinearity, multiphoton absorption and gain dispersion.
B. A. Malomed (14357538)   +3 more
core   +1 more source

Toxic trajectories: Modeling heavy metal-laden phosphate dust dispersion and multi-receptor health risks near Kpémé’s industrial zone

open access: yesResults in Engineering
Industrial emissions in developing regions pose catastrophic yet unquantified health-ecological threats, exemplified by Togo’s Kpémé phosphate plant. Current approaches fail to resolve atmospheric dispersion dynamics of toxic metal-laden TSP (e.g., Cd ...
Daouda Sama   +7 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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