Results 51 to 60 of about 11,339 (266)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Resistência à flexão e compressão em geopolímero com incorporação de nanotubos de carbono [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Civil, Florianópolis, 2014O geopolímero é tratado como uma alternativa ao cimento Portland, sendo a menor quantidade de CO2 ...
Goldoni, Alessandro Graeff
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Nanomaterials for ballistic protection: Advances and future prospects-a review

Results in Engineering
The increasing lethality of ballistic threats and the increasing demand for lightweight and portable protection have revealed the critical limitations of conventional armor materials, such as high material density, poor flexibility, and limited multi-hit
Tibebu Merde Zelelew, Firdwoyn Siyoum Haile, Tsedale Mequanent Admasu, Mestawet Girma Bekele   +3 more
doaj   +1 more source

Multi‐scale spatial dynamics of the Chesapeake Bay nettle, Chrysaora chesapeakei

Ecosphere, 2020
Untangling organisms' multi‐scale spatial distributions is challenging due to their interactions with environments at multiple spatial and temporal scales.
Suzan Shahrestani, Hongsheng Bi, Dong Liang, Katelynn Lankowicz, Chunlei Fan   +4 more
doaj   +1 more source

New indices for the spatial validation of plume forecasts with observations of smoke plumes from grassfires [PDF]

, 2013
The purpose of this work is to propose new indices for the spatial validation of hazardous plumes forecast, and apply and test them with data of a case study.
Blanco, Joaquin Esteban, Berri, Guillermo Jorge   +1 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source