Results 21 to 30 of about 562,363 (310)

Top antiviral hits.

, 2022
Top antiviral hits.
Maureen J. Donlin (10306905), Mariah Hassert (5746874), Ryan P. Murelli (1494397), Valerie Murphy (13812885), Feng Cao (38032), Nana B. Agyemang (13812903), Amelia K. Pinto (6988388), Alex J. Berkowitz (11927369), Bahaa Elgendy (5946035), Andreu Gazquez Casals (13812891), Erofili Giannakopoulou (13812897), Grigoris Zoidis (1279146), John E. Tavis (9204487), Mohamed Elagawany (2592532), Daniel V. Schiavone (13812900), James D. Brien (6988385), Elizabeth Geerling (9566942), Maria C. Mai (13812888), E. Taylor Stone (9853918), Austin T. O’Dea (10306902), Vasiliki Pardali (13812894)   +20 more
core   +1 more source

CHROMATOGATE: A TOOL FOR DETECTING BASE MIS-CALLS IN MULTIPLE SEQUENCE ALIGNMENTS BY SEMI-AUTOMATIC CHROMATOGRAM INSPECTION

Computational and Structural Biotechnology Journal, 2013
Automated DNA sequencers generate chromatograms that contain raw sequencing data. They also generate data that translates the chromatograms into molecular sequences of A, C, G, T, or N (undetermined) characters.
Nikolaos Alachiotis, Emmanouella Vogiatzi, Pavlos Pavlidis, Alexandros Stamatakis   +3 more
doaj   +1 more source

Insights on monkeypox disease and its recent outbreak with evidence of nonsynonymous missense mutation

Future Science OA, 2023
The 2022 monkeypox outbreak has created a new global health threat and pandemic. Monkeypox virus is a descendant of the genus Orthopoxvirus, producing a febrile skin rash disease in humans.
Shaza M Elhusseiny, Abraam S Bebawy, Bishoy T Saad, Khaled M Aboshanab   +3 more
doaj   +1 more source

Top vaccination-dependent hits.

, 2022
Top vaccination-dependent hits.
Martin Jankowiak (13892352), Fritz H. Obermeyer (14248226), Jacob E. Lemieux (6504347)   +2 more
core   +1 more source

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Nature, 2008
Protein–RNA interactions have critical roles in all aspects of gene expression. However, applying biochemical methods to understand such interactions in living tissues has been challenging.
D. D. Licatalosi, Aldo Mele, J. Fak, J. Ule, M. Kayikci, S. Chi, Tyson A. Clark, A. Schweitzer, J. Blume, Xuning Wang, J. Darnell, R. Darnell   +11 more
semanticscholar   +1 more source

Two hits to the renin‐angiotensin system may play a key role in severe COVID‐19

Kaohsiung Journal of Medical Sciences, 2020
The spike glycoprotein on the virion surface docking onto the angiotensin‐converting enzyme (ACE) 2 dimer is an essential step in the process of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in human cells—involves downregulation
Yu-Hsin Tseng, Rei-Cheng Yang, Tzong-Shi Lu   +2 more
semanticscholar   +1 more source

Deep-HiTS: Rotation Invariant Convolutional Neural Network for Transient Detection [PDF]

arXiv.org, 2017
We introduce Deep-HiTS, a rotation-invariant convolutional neural network (CNN) model for classifying images of transient candidates into artifacts or real sources for the High cadence Transient Survey (HiTS).
G. Cabrera-Vives, I. Reyes, F. Förster, P. Estévez, J. Maureira   +4 more
semanticscholar   +1 more source

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

Genetics in Medicine, 2018
Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors.
M. Yurgelun, A. Chittenden, V. Morales-Oyarvide, D. Rubinson, R. Dunne, Margaret M. Kozak, Z. Qian, M. Welch, L. Brais, Annacarolina F. L. Da Silva, J. Bui, C. Yuan, Ting-Ting Li, Wan-Ying Li, A. Masuda, Man-Cang Gu, A. Bullock, D. Chang, Thomas E. Clancy, D. Linehan, Jennifer J. Findeis-Hosey, L. Doyle, A. Thorner, Matthew D. Ducar, Bruce M. Wollison, Natalia Khalaf, K. Perez, S. Syngal, Andrew J. Aguirre, W. Hahn, M. Meyerson, C. Fuchs, S. Ogino, J. Hornick, A. Hezel, A. Koong, J. Nowak, B. Wolpin   +37 more
semanticscholar   +1 more source

Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data

SLAS discovery : advancing life sciences R & D, 2020
Phenotypic profiling assays are untargeted screening assays that measure a large number (hundreds to thousands) of cellular features in response to a stimulus and often yield diverse and unanticipated profiles of phenotypic effects, leading to challenges
Johanna Nyffeler, D. Haggard, C. Willis, R. Setzer, R. Judson, K. Paul-Friedman, L. Everett, J. Harrill   +7 more
semanticscholar   +1 more source

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

Antioxidants and Redox Signaling, 2019
Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray.
P. Wijnker, V. Sequeira, D. Kuster, J. van der Velden   +3 more
semanticscholar   +1 more source