Results 121 to 130 of about 24,860,034 (345)
Viruses, 2019 Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission.
Alexis Kafando +11 more
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Detection of HIV-1-infected cells from patients using nonisotopic in situ hybridization [PDF]
, 1989 RH Singer +3 more
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Cell, 2008 RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS.
openaire +2 more sources
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source
Origins of the Aids Viruses, Hiv-1 and Hiv-2: Fact or Fiction? Discussion Paper [PDF]
, 1988 John Seale
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Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines
Advanced Science, EarlyView.This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li +11 more
wiley +1 more source
Drug Resistance to HIV-1 Integrase Inhibitors Among Treatment-Naive Patients in Beijing, China
Pharmacogenomics and Personalized Medicine, 2022 Fengting Yu,1,2,* Qun Li,1,2,* Linghang Wang,1,2 Hongxin Zhao,1,2 Hao Wu,3 Siyuan Yang,1,2 Yunxia Tang,1,2 Jiang Xiao,1,2 Fujie Zhang1,2 1Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Clinical Center ...
Yu F +8 more
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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Advanced Science, EarlyView.Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong +18 more
wiley +1 more source
Second European Round Table on the Future Management of HIV
Journal of Virus Eradication, 2015 The Second European Round Table on the Future Management of HIV took place in Barcelona, 10–11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI).
Casper Rokx +14 more
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