Results 131 to 140 of about 25,225,361 (379)
HIV-1 detection in the olfactory mucosa of HIV-1-infected participants
AIDS, 2019 HIV infection chronically affects the central nervous system (CNS). Olfactory mucosa is a unique site in the respiratory tract that is directly connected to the CNS; thus we wanted to evaluate olfactory mucosa as a surrogate of CNS sampling.We conducted a preliminary study examining HIV populations and susceptible cells in the olfactory mucosa ...
Bertero, Luca +14 more
openaire +5 more sources
Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]
, 2019 Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els +7 more
core +1 more source
Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity
Advanced Science, EarlyView.SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li +8 more
wiley +1 more source
Antiviral Therapy, 2008 Background Perinatal HIV-1 infection is acquired in the milieu of a developing immune system, leading to high levels of uncontrolled viral replication. Few data have been reported that address the viral dynamics and immunological response in infants who initiated aggressive antiretroviral therapy (ART) shortly after birth.
M. Zanchetta +8 more
openaire +5 more sources
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source
Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency
Frontiers in Cellular and Infection Microbiology, 2023 Alexander O. Pasternak +4 more
doaj +1 more source
Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids
Computational and Mathematical Biophysics, 2014 Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids.
Sadre-Marandi Farrah +3 more
doaj +1 more source
Advanced Science, EarlyView.This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo +17 more
wiley +1 more source
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Nature, 2018 Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal ...
Pilar Mendoza +35 more
semanticscholar +1 more source
Advanced Science, EarlyView.High‐fidelity Nanopore sequencing offers a cost‐effective, portable path to uncovering viral dark matter in complex environments—but suffers from severe read‐length bias, low throughput, and limited accuracy. This study traces these limitations to core biochemical barriers and introduces CLAE, a foundational high‐fidelity platform that enables accurate,
Hannah Yu +14 more
wiley +1 more source