Results 131 to 140 of about 707,804 (298)

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Phenylethanoids from the Roots of Codonopsis cordifolioidea and Their Anti HIV-1 Activities

, 2013
Yanqiong Shen, Jian-Hua Yao, Li‐Dan Shu, Liying Yang, Xuemei Gao, Qiu-Fen Hu   +5 more
openalex   +1 more source

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors [PDF]

, 2013
S. Munir Alam, S. Moses Dennison, Baptiste Aussedat, Yusuf Vohra, Peter K. Park, Alberto Fernández‐Tejada, Shelley Stewart, Frederick H. Jaeger, Kara Anasti, Julie Blinn, Thomas B. Kepler, Mattia Bonsignori, Hua‐Xin Liao, Joseph Sodroski, Samuel J. Danishefsky, Barton F. Haynes   +15 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Decision letter: How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

, 2013

openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Evaluation of HIV-1 DNA resistance evolution in highly treatment-experienced and multi-resistant individuals under suppressive antiretroviral therapy: a longitudinal study from the PRESTIGIO Registry [PDF]

Daniele Armenia, Giovanni Marchegiani, Vincenzo Spagnuolo, Maria Concetta Bellocchi, Laura Galli, Tommaso Clemente, Luca Carioti, Riccardo Lolatto, Sergio Ferrara, Roberta Gagliardini, Giulia Marchetti, Carlo Torti, Chiara Fornabaio, Maurizio Zazzi, Antonella Castagna, Maria Mercedes Santoro, Daniele Armenia, Francesco Saladini, Maria Mercedes Santoro, Maurizio Zazzi, Marcello Tavio, Alessandra Mataloni Paggi, Silvia Magnani, Manuela Colafigli, Ornella Schioppa, Stefania Zanussi, Valentina Da Ros, Simone Rossetto, Annalisa Saracino, Flavia Balena, Laura Comi, Daniela Valenti, Pierluigi Viale, Leonardo Calza, Federica Malerba, Silvia Cretella, Riccardo Riccardi, Francesco Castelli, Emanuele Focà, Davide Minisci, Barbara Menzaghi, Maddalena Farinazzo, C Abeli, Bruno Cacopardo, Benedetto Maurizio Celesia, Michele Salvatore Paternò Raddusa, Carmen Giarratana, Paolo Fusco, Vincenzo Olivadese, Simona Mongiardi, Angelo Pan, Chiara Fornabaio, Paola Brambilla, Alessandro Bartoloni, Filippo Lagi, Paola Corsi, Trevisan Sasha, Giuseppe Gullo, Cecilia Costa, Alessio Bellucci, Elisa Mariabelli, Teresa Santantonio, Sergio Lo Caputo, A Narducci, Emanuele Pontali, Marcello Feasi, Antonio Sarà, Matteo Bassetti, Antonio Di Biagio, Sabrina Blanchi, Stefania Piconi, Martina Bottanelli, Silvia Pontiggia, Valsecchi Giada, Stefano Rusconi, Cinzia Bassoli, Francesco Bassani, Liana Bevilacqua, Antonella Castagna, Vincenzo Spagnuolo, Camilla Muccini, Elisabetta Carini, Sabrina Bagaglio, Riccardo Lolatto, Nicolò Capra, Andrea Galli, Rebecka Papaioannu Borjesson, Tommaso Clemente, Golnaz Torkjazi, Girolamo Piromalli, Spinello Antinori, Arianna Narducci, Tiziana Formenti, Giulia Marchetti, Lidia Gazzola, Fabiana Trionfo Fineo, Massimo Puoti, Cristina Moioli, Federico D’Amico, Simoncini Elena   +99 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Hopf bifurcation of an HIV-1 virus model with two delays and logistic growth [PDF]

, 2020
Caixia Sun, Lele Li, Jianwen Jia
openalex   +1 more source