Results 231 to 240 of about 707,804 (298)

Hepatitis A Virus Outbreak; a Possible Indicator of High Risk Sexual Behavior among HIV-1 Infected Homosexual Men

, 1999
Taro Kojima, Natsuo Tachikawa, Sadako Yosizawa, Chie Yasuoka, Yoshihiko Yamamoto, Ikumi Genka, Katsuji Teruya, Yoshimi Kikuchi, Makoto Aoki, Akira Yasuoka, Shinichi Oka   +10 more
openalex   +2 more sources

A Riboflavin‐Derived Flavinium Salt Mediates Chemoselective Methylation Reactions

Chemistry – A European Journal, EarlyView.
A two‐component methylation protocol was developed, where the active flavin mediator can be recycled in a single step. Crystallographic data and NMR spectroscopy support the mechanistic proposal, while chemoselective methylation was observed for a broad range of biologically relevant substrates. ABSTRACT Selective methylation is among the most relevant
Tim Langschwager, Ekrem Suylu, Julian Zuber, Golo Storch   +3 more
wiley   +1 more source

Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]

PLoS One
Fekri M, Bolhassani A, Movahedi M, Rahmati F.   +3 more
europepmc   +1 more source

HIV-1 fitness landscape models for indinavir treatment pressure using observed evolution in longitudinal sequence data are predictive for treatment failure

, 2013
Raphael Zozimus Sangeda, Kristof Theys, Gertjan Beheydt, Soo‐Yon Rhee, Koen Deforche, Jurgen Vercauteren, Pieter Libin, Stijn Imbrechts, Zehava Grossman, Ricardo Camacho, Kristel Van Laethem, Alejandro Pironti, Maurizio Zazzi, Anders Sönnerborg, Francesca Incardona, Andrea De Luca, Carlo Torti, Lı́dia Ruiz, David van de Vijver, Robert W. Shafer, Bianca Bruzzone, Eric Van Wijngaerden, Anne–Mieke Vandamme   +22 more
openalex   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Interferons in HIV-1 infection: mechanisms, antiviral potentials, and therapeutic challenges. [PDF]

Front Immunol
Zhu L, Ji J, Xiao J, Wang F, Yu J, Liu Y, Zhang Y, Wu H, Su B, Lu X, Zhang T.   +10 more
europepmc   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Designing Potent HIV‑1 Protease Inhibitors Using Machine Learning and QSAR Approaches. [PDF]

ACS Omega
Ali S, Dwi Putra I, Chuntakaruk H, Wolschann P, Maitarad P, Rungrotmongkol T, Hannongbua S.   +6 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source