Results 11 to 20 of about 42,534 (266)

Integrase and integration: biochemical activities of HIV-1 integrase [PDF]

Retrovirology, 2008
Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration.
Deprez Eric, Saïb Ali, Carayon Kevin, Delelis Olivier, Mouscadet Jean-François   +4 more
doaj   +3 more sources

HIV-1 Integrase-DNA Recognition Mechanisms [PDF]

Viruses, 2009
Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and
Mamuka Kvaratskhelia, Ari Katz, Nikolozi Shkriabai, Jocelyn O. Eidahl, Christopher J. McKee, Jacques J. Kessl   +5 more
doaj   +3 more sources

Arylamide Inhibitors of HIV-1 Integrase

Journal of Medicinal Chemistry, 1997
Based on data derived from a large number of HIV-1 integrase inhibitors, similar structural features can be observed, which consist of two aryl units separated by a central linker. For many inhibitors fitting this pattern, at least one aryl ring also requires ortho bis-hydroxylation for significant inhibitory potency.
He Zhao, Nouri Neamati, Abhijit Mazumder, Sanjay Sunder, Yves Pommier, Terrence R. Burke   +5 more
openalex   +3 more sources

HIV-1 Integrase T218I/S Polymorphisms Do Not Reduce HIV-1 Integrase Inhibitors' Phenotypic Susceptibility. [PDF]

AIDS Res Hum Retroviruses
The recently Food and Drug Administration (FDA)-approved cabotegravir (CAB) has demonstrated efficacy as an antiretroviral agent for HIV treatment and prevention, becoming an important tool to stop the epidemic in the United States of America (USA).
Rodríguez-López ER, López P, Rodríguez Y, Sánchez R, Acevedo VS, Encarnación J, Tirado G, Ortiz-Sánchez C, Mesplède T, Rivera-Amill V.   +9 more
europepmc   +3 more sources

Authentic HIV-1 Integrase Inhibitors [PDF]

Future Medicinal Chemistry, 2010
HIV-1 integrase (IN) is indispensable for HIV-1 replication and has become a validated target for developing anti-AIDS agents. In two decades of development of IN inhibition-based anti-HIV therapeutics, a significant number of compounds were identified as IN inhibitors, but only some of them showed antiviral activity.
Chenzhong, Liao, Christophe, Marchand, Terrence R, Burke, Yves, Pommier, Marc C, Nicklaus   +4 more
openaire   +2 more sources

Fungal Phenalenones Inhibit HIV-1 Integrase [PDF]

The Journal of Antibiotics, 2005
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied.
Kazuro, Shiomi, Ryosuke, Matsui, Miki, Isozaki, Harumi, Chiba, Takahiro, Sugai, Yuichi, Yamaguchi, Rokuro, Masuma, Hiroshi, Tomoda, Tomoko, Chiba, Hua, Yan, Yoshihiro, Kitamura, Wataru, Sugiura, Satoshi, Omura, Haruo, Tanaka   +13 more
openaire   +2 more sources

Integrase deficient lentiviral vector: prospects for safe clinical applications [PDF]

PeerJ, 2022
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new ...
Chee-Hong Takahiro Yew, Narmatha Gurumoorthy, Fazlina Nordin, Gee Jun Tye, Wan Safwani Wan Kamarul Zaman, Jun Jie Tan, Min Hwei Ng   +6 more
doaj   +2 more sources

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design. [PDF]

PLoS ONE, 2012
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to the lens epithelium derived growth factor (LEDGF) binding site of the integrase catalytic core domain.
Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, Lisa J Clark, Eric D Jones, Jonathan A V Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H Ryan, G Paul Savage, Craig L Francis, John J Deadman   +15 more
doaj   +1 more source

Clinical use of HIV integrase inhibitors : a systematic review and meta-analysis [PDF]

, 2013
Background: Optimal regimen choice of antiretroviral therapy is essential to achieve long-term clinical success. Integrase inhibitors have swiftly been adopted as part of current antiretroviral regimens.
A Talbot, AJ Viera, Annemarie M. J. Wensing, AR Zolopa, Axel Fun, B Grinsztejn, B Taiwo, B Young, C Cohen, C Garrido, D McMahon, D Moher, DK Owens, DV Cordery, E DeJesus, E Martinez, E Vispo, EM Gardner, F Caby, F Canducci, F Smith, H Byakwaga, H Hatano, J Reynes, J van Lunzen, JJ Eron, JJ Eron Jr, JK Rockstroh, JL Lennox, JL Lennox, JM Gatell, JM Molina, JR Santos, L Van Wesenbeeck, L Wittkop, Linos Vandekerckhove, Luis Menéndez-Arias, M Harris, M Markowitz, M Markowitz, MA Thompson, MJ Buzon, MJ Kozal, Monique Nijhuis, N Mantel, Nele Brusselaers, O Goethals, PE Sax, Peter Messiaen, R Qaqish, R Relevo, RT Gandhi, RT Gandhi, RT Steigbigel, RT Steigbigel, S Gallien, S Nozza, V Dahl, W Towner, Y Yazdanpanah   +59 more
core   +8 more sources

HIV-1 Integrase: From Biology to Chemotherapeutics [PDF]

Current HIV Research, 2007
AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be compromised by the development of ...
Zeinalipour-Loizidou, E., Nicolaou, Charalambos P., Nicolaïdes, Andrew N., Kostrikis, Leontios G., Zeinalipour-Loizidou, E., Nicolaou, Charalambos P., Nicolaïdes, Andrew N., Kostrikis, Leontios G.   +7 more
openaire   +4 more sources