Results 31 to 40 of about 30,382,849 (226)

The first total synthesis of lamellarin α 20-sulfate, a selective inhibitor of HIV-1 integrase [PDF]

, 2006
The first total synthesis of lamellarin α 20-sulfate (1), a selective inhibitor of HIV-1 integrase, has been completed. The lamellarin α core in which 13-OH and 20-OH were differentially protected by isopropyl and benzyl groups, respectively, was ...
Iwao, Masatomo, Ishibashi, Fumito, Yamaguchi, Tomohiro, Fukuda, Tsutomu   +3 more
core   +1 more source

Fungal Phenalenones Inhibit HIV-1 Integrase [PDF]

The Journal of Antibiotics, 2005
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied.
Kazuro, Shiomi, Ryosuke, Matsui, Miki, Isozaki, Harumi, Chiba, Takahiro, Sugai, Yuichi, Yamaguchi, Rokuro, Masuma, Hiroshi, Tomoda, Tomoko, Chiba, Hua, Yan, Yoshihiro, Kitamura, Wataru, Sugiura, Satoshi, Omura, Haruo, Tanaka   +13 more
openaire   +2 more sources

Patterns of resistance development with integrase inhibitors in HIV [PDF]

, 2011
Jean L Mbisa, Supang A Martin, Patricia A CaneVirus Reference Department, Microbiology Services, Health Protection Agency, London, UKAbstract: Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed ...
Patricia A Cane, null Mbisa, Jean L Mbisa, null Martin, Supang A Martin, Pat Cane   +5 more
core   +1 more source

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

Viruses, 2021
There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genotypic
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Tshenolo Ntsipe, Nametso Mathiba, Mompati Mogwele, Max Kapanda, Bornapate Nkomo, Dinah Ramaabya, Joseph Makhema, Mompati Mmalane, Madisa Mine, Ishmael Kasvosve, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe   +15 more
doaj   +1 more source

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

, 2019
A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived-growth-factor-p75 (LEDGF/p75)-binding site on HIV-1 integrase, an attractive target for antiviral chemotherapy, was prepared and screened for ...
Timothy Connolly (1754563), Dawn D. Parker (1834201), Christopher Cianci (6240926), Susan Jenkins (1834318), Kevin M. Peese (1457527), Barry L. Johnson (6240911), Robert T. Nolte (471200), Chen Li (54018), Hal A. Lewis (1399384), Christopher W. Allard (6240908), Brian McAuliffe (6240920), Nicholas A. Meanwell (362044), Manoj Patel (6240914), Mark Krystal (364355), Ping Zhang (86495), Michael A. Walker (1754566), Beatrice Minassian (6240923), Kevin Kish (1399378), Jean Simmermacher (5101232), Margaret E. Sorensen (6240917), B. Narasimhulu Naidu (2686801)   +20 more
core   +2 more sources

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Virology Journal, 2019
Background HIV-1 hijacks the cellular machinery for its own replication through protein-protein interactions between viral and host cell factors. One strategy against HIV-1 infection is thus to target these key protein complexes.
Fadila Larguet, Clément Caté, Benoit Barbeau, Eric Rassart, Elsy Edouard   +4 more
doaj   +1 more source

Stereospecificity of Reactions Catalyzed by HIV-1 Integrase [PDF]

Journal of Biological Chemistry, 1999
The retroviral integrase catalyzes two successive chemical reactions essential for integration of the retroviral genome into a host chromosome: 3' end processing, in which a dinucleotide is cleaved from each 3' end of the viral DNA; and the integration reaction itself, in which the resulting recessed 3' ends of the viral DNA are joined to the host DNA.
J L, Gerton, D, Herschlag, P O, Brown
openaire   +2 more sources

Innate sensing of HIV-infected cells [PDF]

, 2011
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells.
Richard E. Randall, Randall, Richard E, Mustapha Si-Tahar, Helen K W Law, Julien Pothlichet, Plumas, Joel, Lepelley, Alice, Mammano, Fabrizio, Helen K. W. Law, Richard E Randall, Schwartz, Olivier, Albert, Matthew L, Albert, Matthew L., Louis, Stephanie, Laurence Chaperot, Chaperot, Laurence, Stéphanie Louis, Pothlichet, Julien, Olivier Schwartz, Si-Tahar, Mustapha, Sourisseau, Marion, Schilte, Clementine, Law, Helen K. W., Law, Helen K W, Marion Sourisseau, Joël Plumas, Alice Lepelley, Clémentine Schilte, Fabrizio Mammano, Matthew L Albert, Matthew L. Albert, Randall, Richard Edward   +31 more
core   +2 more sources

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

eLife, 2020
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication.
Jennifer L Elliott, Jenna E Eschbach, Pratibha C Koneru, Wen Li, Maritza Puray-Chavez, Dana Townsend, Dana Q Lawson, Alan N Engelman, Mamuka Kvaratskhelia, Sebla B Kutluay   +9 more
doaj   +1 more source

HIV‐1 Integrase Inhibition of Biscoumarin Analogues.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Su, Chang-Xiao, Mouscadet, Jean-Francois, Chiang, Chih-Chia, Tsai, Hou-Jen, Hsu, Ling-Yih   +4 more
openaire   +3 more sources