Results 21 to 30 of about 30,382,849 (226)

HIV-1 Integrase and ALLINI Structure.

, 2023
A. Domain Map of HIV-1 Integrase. B. The preclinical lead ALLINI BI-224436. Chemical features common to the ALLINI class are highlighted, including a carboxylic acid moiety (salmon), a tert-butoxy moiety (green), and a large hydrophobic appendage at the ...
Audrey Allen (9324850), Saira Montermoso (14717014), Hemma Murali (14717017), Frederic D. Bushman (22634), Robert Sharp (2685574), Kushol Gupta (1435129), Young Hwang (3389213), Grant Eilers (3389222), Gregory Van Duyne (9324856)   +8 more
core   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases, 2010
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.
Daria J. Hazuda, PhD
doaj   +1 more source

Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

mBio, 2020
Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is ...
Ishak D. Irwan, Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, Bryan R. Cullen   +4 more
doaj   +1 more source

Three main mutational pathways in HIV-2 lead to high-level raltegravir and elvitegravir resistance: implications for emerging HIV-2 treatment regimens. [PDF]

PLoS ONE, 2012
Human immunodeficiency virus type 2 (HIV-2) is intrinsically resistant to non-nucleoside reverse transcriptase inhibitors and exhibits reduced susceptibility to several of the protease inhibitors used for antiretroviral therapy of HIV-1. Thus, there is a
Robert A Smith, Dana N Raugi, Charlotte Pan, Matthew Coyne, Alexandra Hernandez, Brad Church, Kara Parker, James I Mullins, Papa Salif Sow, Geoffrey S Gottlieb, University of Washington-Dakar HIV-2 Study Group   +10 more
doaj   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors

Viruses, 2010
The HIV-1 integrase enzyme is essential for integrating the viral DNA into the host chromosome. Infection is aborted in the absence of integration, making integrase an attractive antiviral target. Recently approved inhibitors of integrase bind tightly to
Robert Craigie, Zhiqi Yin
doaj   +1 more source

Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

Infectious Disease Reports, 2022
HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance.
Helene Mens, Lasse Fjordside, Jannik Fonager, Jan Gerstoft   +3 more
doaj   +1 more source

Characterization of natural polymorphic sites of the HIV‐1 integrase before the introduction of HIV‐1 integrase inhibitors in Germany [PDF]

Journal of the International AIDS Society, 2014
IntroductionThe aim of our study was to analyze the occurrence and evolution of HIV‐1 integrase polymorphisms during the HIV‐1 epidemic in Germany prior to the introduction of the first integrase inhibitor raltegravir in 2007.Materials and MethodsPlasma samples from drug‐naïve HIV‐1 infected individuals newly diagnosed between 1986 and 2006 were used ...
Meixenberger, Karolin, Yousef, Kaveh Pouran, Somogyi, Sybille, Fiedler, Stefan, Bartmeyer, Barbara, Kleist, Max von, Kücherer, Claudia   +6 more
openaire   +3 more sources

Novel machine learning approach toward classification model of HIV-1 integrase inhibitors. [PDF]

RSC Adv
HIV-1 (Human immunodeficiency virus-1) has been causing severe pandemics by attacking the immune system of its host. Left untreated, it can lead to AIDS (acquired immunodeficiency syndrome), where death is inevitable due to opportunistic diseases ...
Phan TL, Trinh TC, To VT, Pham TA, Van Nguyen PC, Phan TM, Truong TN.   +6 more
europepmc   +4 more sources

Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. [PDF]

ACS Omega, 2022
Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS). HIV-1, like all retroviruses, stably integrates its vDNA copy into host chromatin, a process allowing for permanent infection. This essential step for HIV-1 replication is catalyzed by viral integrase (IN) and aided by cellular protein LEDGF/p75.
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC.   +9 more
europepmc   +4 more sources