Results 101 to 110 of about 2,775,555 (408)

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, EarlyView.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source

The Coalescence of Intrahost HIV Lineages Under Symmetric CTL Attack [PDF]

arXiv, 2011
Cytotoxic T lymphocytes (CTLs) are immune system cells that are thought to play an important role in controlling HIV infection. We develop a stochastic ODE model of HIV-CTL interaction that extends current deterministic ODE models. Based on this stochastic model, we consider the effect of CTL attack on intrahost HIV lineages assuming CTLs attack ...
arxiv  

Chemsex, sexualized drug use and emotional vulnerability among men who have sex with men (MSM): a one-month survey in a STI/HIV center

BMC Public Health
Background Chemsex, characterized by the intentional use of specific drugs to enhance sexual experiences during group sessions, represents a challenge for the health of some sexually active communities, such as men who have sex with men (MSM).
Stella Capodieci, Mauro Zaccarelli, Christof Stingone, Eugenia Giuliani, Valentina Cafaro, Laura Gianserra, Maria Gabriella Donà, Alessandra Latini, Massimo Giuliani   +8 more
doaj   +1 more source

CD4/CD8 ratio normalization rates and low ratio as prognostic marker for non-AIDS defining events among long-term virologically suppressed people living with HIV

AIDS Research and Therapy, 2018
Background Immune restoration is often incomplete after ART in HIV patients, both quantitatively and qualitatively. We studied the incidence and probability of CD4/CD8 normalization in an adult Thai HIV cohort and explored the predictive value of the ...
Win Min Han, Tanakorn Apornpong, Stephen J. Kerr, Akarin Hiransuthikul, Sivaporn Gatechompol, Tanya Do, Kiat Ruxrungtham, Anchalee Avihingsanon   +7 more
doaj   +1 more source

HIV ANTIGENAEMIA IN ACUTE HIV INFECTION

The Lancet, 1987
-Human immunodeficiency virus (HIV) infection maypresent as an acute illness, probably occurring shortly after virusacquisition.1.2 Most cases have been diagnosed retrospectivelyfollowing seroconversion. We have seen two patients with a clinicalpicture compatible with acute HIV disease, and have tested theiracute phase sera for HIV antigen.
Wall, R A, Denning, D W, Amos, A
openaire   +2 more sources

Characteristics, Prevention, and Management of Cardiovascular Disease in People Living With HIV: A Scientific Statement From the American Heart Association.

Circulation, 2019
As early and effective antiretroviral therapy has become more widespread, HIV has transitioned from a progressive, fatal disease to a chronic, manageable disease marked by elevated risk of chronic comorbid diseases, including cardiovascular diseases ...
Matthew J. Feinstein, P. Hsue, L. Benjamin, G. Bloomfield, J. Currier, M. Freiberg, S. Grinspoon, J. Levin, C. Longenecker, W. Post   +9 more
semanticscholar   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

Advanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang, Ying Yang, Linlin Xu, Chaoju Hao, Jiaxiang Chen   +4 more
wiley   +1 more source

Low-level genital HIV shedding in Thai HIV-infected women with suppressed plasma viral load after menopause: a longitudinal study

Journal of Virus Eradication, 2017
Objectives: First, to evaluate the longitudinal changes of HIV RNA in genital secretions in HIV-positive women with plasma HIV RNA 50 copies/mL in 27% of the participants, and in 40% after menopause. The GVL was
Nadia Kancheva Landolt, Tanya Do, Naruporn Kasipong, Rosalin Kriengsinyot, Sasiwimol Ubolyam, Apicha Mahanontharit, Tippawan Pankam, Tanakorn Apornpong, Anchalee Avihingsanon, Jintanat Ananworanich, Nittaya Phanuphak, Surasith Chaithongwongwatthana   +11 more
doaj  

Antiretroviral therapy to prevent HIV acquisition in serodiscordant couples in a hyperendemic community in rural South Africa [PDF]

, 2016
Background. Antiretroviral therapy (ART) was highly efficacious in preventing human immunodeficiency virus (HIV) transmission in stable serodiscordant couples in the HPTN-052 study, a resource-intensive randomized controlled trial with near-perfect ART ...
Bärnighausen, Till, De Gruttola, Victor, Harling, Guy, Iwuji, Collins C, Mayer, Kenneth H, Mimiaga, Matthew J, Oldenburg, Catherine E, Pillay, Deenan, Seage III, George R, Tanser, Frank   +9 more
core   +3 more sources

Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE A key factor in assessing the effectiveness and cost-effectiveness of antiretroviral therapy (ART) as a prevention strategy is the absolute risk of HIV transmission through condomless sex with suppressed HIV-1 RNA viral load for both anal and ...
A. Rodger, V. Cambiano, T. Bruun, P. Vernazza, S. Collins, J. van Lunzen, G. Corbelli, V. Estrada, A. Geretti, A. Beloukas, D. Asboe, P. Viciana, F. Gutiérrez, B. Clotet, C. Pradier, J. Gerstoft, R. Weber, K. Westling, G. Wandeler, J. Prins, A. Rieger, M. Stoeckle, T. Kümmerle, T. Bini, A. Ammassari, R. Gilson, I. Krznaric, M. Ristola, R. Zangerle, Pia Handberg, A. Antela, S. Allan, A. Phillips, J. Lundgren   +33 more
semanticscholar   +1 more source