Results 101 to 110 of about 1,402,138 (245)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.

New England Journal of Medicine, 2009
S. Rerks-Ngarm, P. Pitisuttithum, S. Nitayaphan, J. Kaewkungwal, J. Chiu, R. Paris, Nakorn Premsri, C. Namwat, M. de Souza, Elizabeth Adams, M. Benenson, S. Gurunathan, Jim Tartaglia, J. McNeil, D. Francis, D. Stablein, D. Birx, S. Chunsuttiwat, C. Khamboonruang, P. Thongcharoen, M. Robb, Nelson L. Michael, P. Kunasol, Jerome H. Kim   +23 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

Nature, 1996
T. Dragic, V. Litwin, G. Allaway, S. R. Martin, Yaoxing Huang, K. Nagashima, C. Cayanan, P. Maddon, R. Koup, J. Moore, W. Paxton   +10 more
semanticscholar   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Toxic-Induced Encephalopathy Following Chemsex in a Young HIV-Positive Male: A Complex Case of Acute Cognitive Impairment with Anterograde Amnesia and Behavioral Alterations

Infectious Diseases and Therapy
background A broadened clinical spectrum of concomitant complications emerges among the escalating incidence of substance use, particularly within the ‘chemsex’ context. This case exemplifies the profound neurotoxic repercussions and neurological risk of
Alexy Inciarte, Lorena de la Mora, Emilio Huaier-Arriazu, Berta Torres, Silvia Cañizares, Elizabeth Zamora, Montserrat Laguno, Ana Gonzalez-Cordón, Alberto Foncillas, Ivan Chivite, Júlia Calvo, Juan Ambrosioni, Esteban Martínez, Jose Luis Blanco, J. M. Miro, Maria Martinez-Rebollar, Josep Mallolas   +16 more
doaj   +1 more source

Updated research nosology for HIV-associated neurocognitive disorders

Neurology, 2007
A. Antinori, G. Arendt, J. Becker, B. Brew, D. Byrd, M. Cherner, D. Clifford, P. Cinque, L. Epstein, K. Goodkin, M. Gisslén, I. Grant, R. Heaton, J. Joseph, K. Marder, C. Marra, J. Mcarthur, Michael Nunn, R. Price, L. Pulliam, Kevin R. Robertson, Kevin R. Robertson, N. Sacktor, V. Valcour, V. Wojna   +24 more
semanticscholar   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

New England Journal of Medicine, 2012
J. Baeten, D. Donnell, P. Ndase, N. Mugo, J. Campbell, Jonathan Wangisi, J. Tappero, E. Bukusi, C. Cohen, E. Katabira, A. Ronald, Elioda Tumwesigye, E. Were, K. Fife, J. Kiarie, C. Farquhar, G. John-Stewart, Aloysious Kakia, J. Odoyo, A. Mucunguzi, E. Nakku-Joloba, R. Twesigye, K. Ngure, Cosmas Apaka, H. Tamooh, Fridah Gabona, A. Mujugira, D. Panteleeff, Katherine K. Thomas, L. Kidoguchi, M. Krows, Jennifer Revall, Susan Morrison, Harald S. Haugen, Mira Emmanuel-ogier, Lisa Ondrejcek, R. Coombs, L. Frenkel, C. Hendrix, Namandjé N. Bumpus, D. Bangsberg, J. Haberer, W. Stevens, J. Lingappa, C. Celum   +44 more
semanticscholar   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source