THE CELLULAR RECEPTOR (CD4) OF THE HUMAN IMMUNODEFICIENCY VIRUS IS EXPRESSED ON NEURONS AND GLIAL CELLS IN HUMAN BRAIN [PDF]
, 1987 The peculiar tropism of the human immunodeficiency virus (HIV) for T helper lymphocytes can be explained by a specific interaction between the virus and the CD4 molecule on these cells (1, 2).
Funke, Ilona +4 more
core +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR [PDF]
, 2019 The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who ...
Berenguer, Juan +14 more
core +4 more sources
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Scientific Reports, 2018 The importance of natural IgM antibodies in protection against infections is still emerging and these antibodies have a potential role in the maintenance of homeostasis through clearance of apoptotic bodies, complement-dependent mechanisms, inflammation ...
Claudia Devito +7 more
doaj +1 more source
Diagnostic Efficacy of Photostimulated Chemiluminescence Assay for Detecting Anti-HIV Antibodies: A Retrospective Study. [PDF]
Pol J Microbiol, 2023 Han J, Wang Y, Wang B, Tong H.
europepmc +1 more source
Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination
Advanced Science, EarlyView.Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi +21 more
wiley +1 more source
Nature CommunicationsThe details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear.
Sommer Holmes +34 more
doaj +1 more source
Passive and active antibody studies in primates to inform HIV vaccines
Expert Review of Vaccines, 2018 Introduction: Prevention of infection remains the ultimate goal for HIV vaccination, and there is compelling evidence that antibodies directed to Envelope are necessary to block infection.
Ann J. Hessell +2 more
doaj +1 more source
An injectable CRISPR therapy instructs B cells to produce anti-HIV antibodies. [PDF]
Synth Biol (Oxf), 2022 Collins LT.
europepmc +1 more source