Results 101 to 110 of about 1,212,195 (296)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Human IgM monoclonal antibodies block HIV-transmission to immune cells in cervico-vaginal tissues and across polarized epithelial cells in vitro

Scientific Reports, 2018
The importance of natural IgM antibodies in protection against infections is still emerging and these antibodies have a potential role in the maintenance of homeostasis through clearance of apoptotic bodies, complement-dependent mechanisms, inflammation ...
Claudia Devito, Rada Ellegård, Tina Falkeborn, Lennart Svensson, Mats Ohlin, Marie Larsson, Kristina Broliden, Jorma Hinkula   +7 more
doaj   +1 more source

Diagnostic Efficacy of Photostimulated Chemiluminescence Assay for Detecting Anti-HIV Antibodies: A Retrospective Study. [PDF]

Pol J Microbiol, 2023
Han J, Wang Y, Wang B, Tong H.
europepmc   +1 more source

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference. [PDF]

, 2010
EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines ...
Palma, Paolo, Palma Paolo, Lara Mainetti, Paolo Palma, Grupping, K., Reudelsterz, M., Robin Shattock, Hannes Uchtenhagen, Gabriella Scarlatti, Hallengärd, D, Uchtenhagen, H, Hallengärd David, Shattock Robin, Caroline Weber, Mainetti, Lara, Wahren, Britta, Winni De Haes, Coleman, A., Annette Sköld, Seifried, Janna, Sköld, A, Sköld Annette, Scarlatti, G, Lund University., Selhorst, P., Hornig Julia, van Gils, M. J., De Haes, W., Hornig, Julia, De Haes, W, Klein, K., Seifried Janna, Biswas, P., Da Costa, K., Da Costa Kelly, Da Costa, K, De Haes, Winni, Dieltjens Tessa, Wahren, B., Reudelsterz, Marc, Palma, P., Borggren, Marie,, Dispinseri Stefania, Seifried, J., Uchtenhagen, Hannes, Hornig, J., Borggren, Marie, Da Costa, Kelly, Scarlatti Gabriella, Selhorst, P, Wahren, B, Selhorst Philippe, David Hallengärd, Kelly Da Costa, Katrijn Grupping, Priscilla Biswas, Shattock, R., Katja Klein, Mainetti Lara, Mainetti, L., Janna Seifried, Dieltjens, Tessa, Scarlatti, Gabriella, Klein Katja, Marit J van Gils, Weber, Caroline, Weber, C, De Haes Winni, Uchtenhagen Hannes, Grupping Katrijn, van Gils, M.J., Borggren Marie, Adam Coleman, Weber Caroline, Shattock, R, Hornig, J, van Gils Marit J, Marie Borggren, Borggren, M, Selhorst, Philippe, Costa, Kelly Da, Mainetti, L, Skold, A., Biswas, P, Coleman, Adam, Coleman, A, Stefania Dispinseri, Gils, Marit J. van, Palma, P, Wahren Britta, Marc Reudelsterz, Hallengard, David, Seifried, J, Haes, Winni De, van Gils, MJ, Weber, C., Scarlatti, G., Philippe Selhorst, Biswas Priscilla, Reudelsterz, M, van Gils, Marit J., Klein, K, Hallengard, D., Britta Wahren, Tessa Dieltjens, Borggren, M., Dieltjens, T., Coleman Adam, Grupping, K, Biswas, Priscilla, Skold, Annette, Grupping, Katrijn, Dispinseri, S., Dieltjens, T, Dispinseri, S, Klein, Katja, Reudelsterz Marc, Julia Hornig, Dispinseri, Stefania, Shattock, Robin   +119 more
core   +2 more sources

FREQUENCY OF HEPATITIS B, HEPATITIS C AND HIV INFECTIONS AMONGST EMPLOYEES OF A UNITED NATIONS PEACE KEEPING MISSION

Pakistan Armed Forces Medical Journal, 2014
Objective: To determine the frequency of HBsAg, anti HCV antibodies and anti HIV antibodies amongst UNAMID employees attending our dental clinics. Study Design: Observational study.
Abdul Rehman Arshad, Imran Khan, Aqeel Ibrahim   +2 more
doaj   +2 more sources

The impact of antibodies to human glycoprotein CD4 and gamma-interferon on the t-cell immunity and the cytokine levels in patients co-infected with HIV/HCV during the antiretroviral therapy

Медицинский вестник Юга России, 2017
Objective: This work was to estimate the influence of antibodies to human glycoprotein CD4 and IFN-γ on the T-cell immunity and the cytokine levels in patients with HIV and HIV/HCV during the standard antiretroviral therapy.
A. V. Strygin, A. M. Docenko, A. O. Strygina, E. I. Morkovin, V. I. Petrov   +4 more
doaj   +1 more source

An injectable CRISPR therapy instructs B cells to produce anti-HIV antibodies. [PDF]

Synth Biol (Oxf), 2022
Collins LT.
europepmc   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Association of CD4 cell count and antiretroviral therapy antibody production in Human Immunodeficiency virus seropositive subjects on antiretroviral drugs in Benin City, Nigeria.

Sokoto Journal of Medical Laboratory Science, 2022
Antiretroviral therapy (ART) is widely used and subjects on ART were reported to develop antibodies against these drugs when used as monotherapy. The aim of this study was to determine the proportion of HIV-sero positive subjects on antiretroviral ...
Progress Arhenrhen OBAZELU* 1 and Mathias Abiodun EMOKPAE 1
doaj