Results 211 to 220 of about 308,174 (298)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Development of HIV Drug-Resistance Mutations and Antiretroviral Efficacy Among Vietnamese Patients After Failure of 5-Year First-Line Therapy. [PDF]

J Clin Lab Anal
Hung TM, Bang LVN, Van Duyet L.
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Pretreatment HIV Drug Resistance to Integrase Strand Transfer Inhibitors Among Newly Diagnosed HIV Individuals - China, 2018-2023. [PDF]

China CDC Wkly
Hu H, Hao J, Wang D, Liu X, Chen H, Li F, Chen J, Li M, Xin P, Li Y, Li Q, Li H, Li J, Hu J, Song C, Feng Y, Liao L, Ruan Y, Xing H.   +18 more
europepmc   +1 more source

“Working the Pages”: Entrepreneurship Strategies of Venezuelan Trans Women Refugees Who Enter Sex Work in Brazil During COVID‐19

Gender, Work &Organization, EarlyView.
ABSTRACT The Venezuelan refugee crisis has displaced nearly 8 million people, with transgender and queer refugees among the most marginalized groups. This paper explores the intersecting precarity and entrepreneurship of Venezuelan trans women refugees who became sex workers in Brazil during COVID‐19.
Yvonne Su, Tyler Valiquette, David J. Kinitz, Clara de Oliveira Cunha   +3 more
wiley   +1 more source

Epidemiological dynamics and molecular characterization of HIV drug resistance in eastern China from 2020 to 2023. [PDF]

Front Microbiol
Zhu M, Sun Z, Zhang X, Luo W, Wu S, Ye L, Xu K, Chen J.   +7 more
europepmc   +1 more source

Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh, Julia C. Stingl, Marco Stadler, Anja Reichert, Heiner Wedemeyer, Johannes Oldenburg   +5 more
wiley   +1 more source

Cost-effectiveness of pretreatment HIV drug resistance testing in people living with HIV in Iran. [PDF]

PLoS One
Mirzaei H, Iranpour A, Esmaeilzadeh F, Barouni M, Mehrabi F, Ranjbar E, Sharifi H.   +6 more
europepmc   +1 more source

Treatment durability, satisfaction and quality of life in virologically suppressed HIV‐1 people switching to doravirine: Results from the French study DoraVIH

HIV Medicine, EarlyView.
Abstract Objectives In Europe, most people with HIV‐1(PWH) achieve virologic suppression with effective and well‐tolerated antiretroviral therapies (ART). In this context, patient‐reported outcomes (PRO) are increasingly important for evaluating ART benefits.
Spire Bruno, Robineau Olivier, Pourcher Valérie, Loubet Paul, Palacios Christia, Jacomet Christine, Benachir Haydar, Mariot Philippe, Parienti Jean‐Jacques, Slama Laurence   +9 more
wiley   +1 more source

Viral Suppression and HIV Drug Resistance Among Patients on Second-Line Antiretroviral Therapy in Selected Health Facility in Ethiopia. [PDF]

Viruses
Zealiyas K, Gebreegziabxier A, Getaneh Y, Kidane E, Woldesemayat B, Yizengaw A, Gutema G, Adane S, Yimer M, Yilma A, Tadele S, Sasinovich S, Medstrand P, Arimide DA.   +13 more
europepmc   +1 more source