Results 211 to 220 of about 36,030 (253)

HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells

Journal of Cellular Biochemistry, 2000
Glomerular epithelial cells (GEC) have been demonstrated to undergo morphological alterations in human immunodeficiency virus (HIV)-associated focal glomerulosclerosis. In the present study, we evaluated the effect of HIV-1 gp120 envelope protein on the growth of cultured human (H) GEC.
P C, Singhal, K, Reddy, N, Franki, G, Ding   +3 more
openaire   +2 more sources

The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion

The Journal of Immunology, 1991
Abstract Results and conclusions concerning the ability of HIV glycoprotein (gp) 120 to stimulate monokine secretion have been equivocal, based on observations using natural gp120 derived from infected human cells and a Chinese hamster ovary (CHO) cell-derived recombinant fusion protein. Current studies were designed to determine whether
K A, Clouse, L M, Cosentino, K A, Weih, S W, Pyle, P B, Robbins, H D, Hochstein, V, Natarajan, W L, Farrar   +7 more
openaire   +2 more sources

Use of Human CD4 Transgenic Mice for Studying Immunogenicity of HIV-1 Envelope Protein gp120

Transgenic Research, 2001
HIV-1 envelope protein, gp120, is a major immunogenic protein of the AIDS virus. A specific feature of this protein is its interaction with the receptor protein, human CD4, an important component of the immune system. This interaction might affect the immunogenic properties of the gp 120 and modulate the immune response towards HIV.
J, Seagal, E, Spectorman, J M, Gershoni, G F, Denisova   +3 more
openaire   +2 more sources

Interaction of several complement proteins with gp120 and gp41, the two envelope gycoproteins of HIV-1

AIDS, 1995
To study the binding of human complement proteins to gp41 and gp120 of HIV-1.The interaction of complement proteins with gp41 and gp120 and their effect on the gp41-gp120 complex in enzyme-linked immunosorbent assays (ELISA) and on stably transfected Schneider-2 cells expressing a gp41-gp120 complex was investigated.
H, Stoiber, C, Ebenbichler, R, Schneider, J, Janatova, M P, Dierich   +4 more
openaire   +2 more sources

Antibody-dependent cellular cytotoxicity is directed against both the gp120 and gp41 envelope proteins of HIV

Aids, 1989
To define the target antigens for antibody-dependent cellular cytotoxicity (ADCC), assays were performed using affinity-purified human immunoglobulin (Ig) or polyclonal rabbit sera directed against specific proteins of HIV. ADCC was not found using affinity-purified anti-core (p25) human Ig or sera obtained from rabbits hyper-immunized with recombinant
L A, Evans, G, Thomson-Honnebier, K, Steimer, E, Paoletti, M E, Perkus, H, Hollander, J A, Levy   +6 more
openaire   +2 more sources

Spatial Structure Model of the CD4 Receptor-Binding Site of the HIV Envelope Protein gp120

Journal of Biomolecular Structure and Dynamics, 1998
In this study we have undertaken attempt to predict 3D structure of the CD4 receptor-binding site of the HIV envelope protein gp120. The structure of this site has been constructed by the analysis of low-energy conformers of peptide T, an HIV reproduction inhibitor with amino acid sequence corresponding to the fragment Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr ...
openaire   +2 more sources

The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: implications for binding to the HIV envelope protein gp120.

Journal of the American Chemical Society, 2001
C. Bewley, S. Otero-Quintero
semanticscholar   +1 more source

HIV-1 envelope protein gp120 impairs intracellular antifungal mechanisms in human monocytes.

1998
The key to success of fungal opportunistic pathogens in the immunocompromised host is related to survival inside phagocytic cells, which represent the first line of defense against microorganisms. The contribution of human immunodeficiency virus-1 recombinant envelope protein gp120 on effector functions of peripheral blood monocytes (PBM) against ...
PIETRELLA, Donatella, MONARI, Claudia, RETINI, Cinzia, PALAZZETTI, BARBARA, BISTONI, Francesco, VECCHIARELLI, Anna   +5 more
openaire   +1 more source

The HIV Envelope Protein gp120 in the Nervous System

Biochemical Pharmacology, 1998
M.Tiziana Corasaniti, Giacinto Bagetta, Domenicantonio Rotiroti, Giuseppe Nisticò   +3 more
openaire   +1 more source

The HIV envelope protein gp120 is toxic to human brain‐cell cultures through the induction of interleukin‐6 and tumor necrosis factor‐&agr;

AIDS (London), 1995
M. C. Yeung, L. Pulliam, A. Lau
semanticscholar   +1 more source